@@ 乏氧是实体肿瘤发展过程中的普遍现象,肿瘤乏氧细胞的存在使肿瘤对放化疗的抗性增加,更容易侵袭和转移.乏氧诱导因子(hypoxia-inducible factors, HIF)调控能量代谢、细胞周期进程和凋亡等相关基因表达使细胞更加适应缺氧微环境,在相关酶或因子的变化过程中起中枢纽带作用.%The expression of miR - 210, a much concened hypoxia - induced molecule, is significantly changed under the condition of hypoxic microenvironment. The up -regulation of miR -210 depends on the expression of hypoxia - inducible factor in different types of hypoxic tumor cells and norm al cells. This review article summarizes the recent progress on the regulation of miR -210 expression and its biological function under hypoxic condition.
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