AIM: To investigate the levels of neuropeptides and electrolytes in the patients with acute traumatic brain injury. METHODS: Seventy- eight patients with acute brain injury were divided into mild, moderate and severe groups according to their GCS scores. The serum levels of arginine vasopressin ( AVP ) and angiotensin Ⅱ ( Aug Ⅱ ) were measured on day 1, 3 and 7 after injury. The serum levels of electrolytes were also measured on day 1. Forty - one subjects who received healthy check - up served as normalcontrols. RESULTS: Compared with normal control group, the serum levels of AVP and Ang Ⅱ significantly increased in the patients with traumatic brain injury ( P ＜ 0.01 ), depending on the severity of brain injury. Both neuropeptides reached the peak on day 3 after injury. The concentrations of serum potassium and calcium decreased in the patients with acute brain injury( P ＜ 0.01 ), also showing a severity -dependent tendency. No significant change of serum sodium in the patients with brain injury was observed. CONCLUSION: The serum levels of arginine vasopressin and angiotensin Ⅱ canalso be used as the severity indicators of traumatic brain injuries. Decrease in serum potassium and calcium can also be used to evaluate the severity in patients with acute traumatic brain injury.%目的:探讨颅脑损伤急性期血浆精氨酸血管加压素(AVP)、血管紧张素Ⅱ(AngⅡ)和电解质水平的变化.方法:根据GCS评分将78例急性颅脑损伤患者分为轻度组、中度组和重度组,测定各组患者损伤后第1、3、7 d 血浆 AVP和AngⅡ水平,入院当天同时测定血浆电解质.另外选择正常对照组41例相比较.结果:与正常对照组相比,颅脑损伤患者AVP和AngⅡ明显增高(P<0.01),颅脑损伤越重,上述指标升高越明显,损伤后第3 d达高峰.颅脑损伤患者血钾、血钙浓度降低(P<0.01),其下降程度与颅脑损伤严重程度相关,轻型颅脑损伤组与对照组比较无显著差异.颅脑损伤后血钠水平无明显变化.结论:血浆AVP和AngⅡ水平的改变可作为判断颅脑损伤严重程度的指标;血钾与血钙降低可以作为颅脑损伤患者病情判断的指标.
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