AIM : To observe the changes of amhulatory blood pressure and morphology of resistance vessel in spontaneously hypertensive rats ( SHR) at different weeks of ages.METHODS : SHR at the ages of 16 - week and 40- week were used.The blood pressure ( BP) was monitored by radiotelemetric technique ( RTT).The data of BP. diurnal variation and the variability were analyzed.RESULTS : The results showed that the falling rate of BP at night in 16 - week group was larger than that in 40 - week group (0.0498 vs 0.0211 , P ＜ 0.05 ) .The BP variability in 40 weeks group was higher than that in 16 - week group.Tunica media area/lumen area ratio of arteria mesenterica was mcreased with aging ( P ＜ 0.05 ) .CONCLUSION: The variability of 24 - hour blood pressure in 40 - week - old SHR is higher than that in 16- week - old SHR.Along with the increase in ages, tunica media vasorum area/lumen area m resistance blood vessel ( arteria mesenterica) increases.%目的:观察不同周龄自发性高血压大鼠(SHR)动态血压变化及阻力血管形态.方法:分别选用16周及40周龄的SHR模型,使用遥感监测技术观察清醒、无拘束SHR的动态血压变化,分析不同周龄SHR的血压昼夜变化及变异度,比较不同周龄SHR阻力血管的形态学变化.结果:40周SHR较16周SHR 24 h血压均值高,但无显著差异;16周SHR夜间血压下降率较40周明显升高(P<0.05);40周SHR 血压变异系数较16周SHR明显增大.肠系膜动脉(阻力血管)中膜面积/管腔面积比值随着周龄的增加而增加,5周、16周与40周相比有显著差异(P<0.05).结论:40周SHR动态观察24 h血压变异度较16周SHR大,且随着周龄的增加,阻力血管(肠系膜动脉)的中膜面积/管腔面积增加.
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