@@ 信号转导及转录激活因子(signal transducer and activator of transcription, STAT)是一组存在于胞浆并在激活后能转入核内的DNA结合蛋白家族,具有信号转导和转录调控的功能.哺乳动物中已发现7种: STAT1、STAT2、STAT3、STAT4、STAT5A、STAT5B和STAT6.STAT蛋白是JAK(Janus kinase)/STAT通路中重要的JAK的底物.%Signal transducer and activator of transcription 3 ( STAT3 ), a kind of potential nuclear factor in cytoplasm, is involved in myocardial protection and hypertrophy, and impacts on the vasculature and the extracellular matrix ECM ) via paracrine pathways. By collecting numerous data from experimental and clinical studies, we provide an overview on STAT3 signaling and summarize the current understanding of the role of STAT3 in cardiac remodeling in this review.
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