@@ 在许多发达国家中,约75%-80% 的高血压患者有不同程度肥胖,65% -75%的原发性高血压患者同时合并有肥胖.随着社会的发展,中国的肥胖性高血压(obesity-related hypertension)患病率也在逐年上升［1-3］.肥胖性高血压为多因疾病,对肥胖性高血压机制的相关研究已成为热点,其形成机制可能涉及胰岛素抵抗、血清脂联素、高瘦素血症、交感系统活化、肾素-血管紧张素系统(renin-angiotensin system, RAS)、凝血因子改变,炎症、内皮功能障碍等,但尚未达成广泛共识［4, 5］.现在越来越多的研究表明,Toll样受体家族（Toll-like receptors,TLRs）与其形成密切相关.深入探讨此种受体的作用,将为肥胖性高血压的治疗提供新的思路.%With increasing accumulation of evidence, obesity - related hypertension is becoming international health problem. However, the pathogenesis and treatment of this disease are still controversial. Recently, there is a widespread concern about the relationship between Toll - like receptors( TLRs ) and the pathogenesis of obesity - related hypertension. The processes from the diet to the metabolism and the possible factors such as fat factors, insulin, adiponectin and renin - angiotensin system that directly lead to obesity - related hypertension are considered to be associated with the functions of TLRs. This paper will try to find the role of TLRs in the pathogenesis of obesity - related hypertension, and provide a new and important perspective for the treatment of this type of hypertension.
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