Midkine (MK) , a newly discovered heparin - binding growth factor, promotes growth, survival, and migration in various cells. Meanwhile, MK stimulates statistically significant forms in new arterioles and capillaries, causes vascular remodeling, prevents ischemia myocardial cells from injury via inhibiting apoptosis. MK also regulates the level of blood - fat. In general, MK plays key roles in cardiovascular diseases.%@@ Midkine(MK)是一种碱性肝素结合生长因子,由121个氨基酸组成,相对分子质量约为13kD,富含碱性氨基酸和半胱氨酸残基,人类的该物质编码序列位于15kb的DNA片段上,编码序列有4个外显子.每一外显子与内含子界面和鼠类多有高度的同源性.
展开▼
