AIM: To find out whether different dosage of rare earth element-lanthanum can influence the expression of aquaporin 7(AQP 7) in the testis of rats. METHODS:Rats were fed with lanthanum nitrate ［La(NO3)3］ and killed 6 months later. Testes were then removed immediately to extract total RNA. Northern blot analysis is performed finally. RESULTS:0.1 mg/kg La(NO3)3 depressed the expression of AQP 7 in rat testis, while 20 mg/kg La(NO3)3 had no significant effect on it. CONCLUSION: AQP 7 expession is found in the rat testis; La(NO3)3 can depress the expression of AQP 7 in the rat testis.%目的：观察不同剂量稀土元素-镧对大鼠睾丸7型水通道(aquaporin 7， AQP 7)基因表达水平的影响。方法：取硝酸镧［La(NO3)3］灌胃6个月大鼠的睾丸组织提取总RNA进行Northern blot 分析。结果：低剂量La(NO3)3（0.1 mg/kg）抑制大鼠睾丸AQP 7的mRNA表达，而高剂量La(NO3)3 (20 mg/kg) 的作用与对照组比较无明显差别。结论：大鼠睾丸内可见AQP 7mRNA的表达；硝酸镧能影响大鼠睾丸AQP 7 mRNA表达的强度。
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