Expression of c-jun in brain stem following moderaternlateral fluid percussion brain injury in rats

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Expression of c-jun in brain stem following moderaternlateral fluid percussion brain injury in rats

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AIM: To study the expression of c-jun in brain stem following moderate lateral fluid percussion brain injury in rats, and to observe the temporal patterns of its expressions following percussion.METHODS: Male Sprague-Dawley rats were divided into normal control, sham operation control and injury groups. The rats of injury group subjected to moderate lateral fluid percussion injury (0.2 mPa), and then were subdivided into 5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 8 h and 12 h groups according to the time elapsed after injury. The expression of c-jun was studied by immunohistochemistry and in situ hybridization. RESULTS: After percussion for 15 min, Jun positive neurons increased in brain stem progressively, and peaked at 12h. At 5min after percussion, the induction of c-jun mRNA was increased, and remained elevated up to 1h-2h after brain injury. CONCLUSION: The induction and expression of the c-jun in brain stem after fluid percussion brain injury were increased rapidly and lasted for a long time.

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《中国病理生理杂志》 |2001年第8期|795|共1页
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Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China;

Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China;

Medical College of Chinese People's Armed Police Forces, Tianjin 300162, China;

West China University of Medical Sciences, Chengdu 610041, China;

West China University of Medical Sciences, Chengdu 610041, China;

West China University of Medical Sciences, Chengdu 610041, China;

West China University of Medical Sciences, Chengdu 610041, China;

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Expression of c-jun in brain stem following moderaternlateral fluid percussion brain injury in rats

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