Tumor necrosis factor -a (TNF- a)was consideral to be a key mediator in the pathogenesis of endotoxin hepatoxicity. However, the precise mechanism by which TNF- a mediate liver injury remains un certain. Many results have shown that TNF - a could mediate neutrophil adherence, activate phospholipase A2, induce Pedction of lipid ndators, fine radicals and so on, all of which played fort role in development of liver injury. This article reviewed recent infonnations about cytotoxic mechanism of TNF -
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