Anti-DR5 monoclonal antibody induces leukemic cell apoptosis

LI Shu-lian; WANG Ji(Laboratory of Cellular and Molecular Immunology; Henan University; Kaifeng 475004; China)

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Anti-DR5 monoclonal antibody induces leukemic cell apoptosis

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The mechanisms for apoptotic induced by anti-DR-5 agnoistic mAb(mDRA-6)were studied with Jurkat and U937 cell.DNA fragmentation,activation of caspase-9,-3 and PARP were observed in Jurkat and U937 cell lines treated by mDRA-6.However,in Jurkat cells,

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《中国病理生理杂志》 |2010年第a10期|2018-2018|共1页
作者
LI Shu-lian; WANG Ji(Laboratory of Cellular and Molecular Immunology; Henan University; Kaifeng 475004; China);
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原文格式 PDF
正文语种 chi
中图分类医学免疫学;
关键词
monoclonal; caspase; fragmentation; PARP; DNA;

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1. Apoptosis of multiple myeloma cells induced by agonist monoclonal antibody against human CD28 [J] . Yu-hua ,Qiu ,Zhong-wen . 中国生物学文摘 . 2006,第001期
2. CXC195 Induce Apoptosis and Endoplasmic Reticulum Stress in Human Non-small cell Lung Cancer Cells Via IRE1α-dependent Pathway [C] . 张洁霞 ,梁颖 . 第九届中国肿瘤内科大会、第四届中国肿瘤医师大会暨中国抗癌协会肿瘤临床化疗专业委员会2015年学术年会 . 2015
3. Levobupivacaine inhibits proliferation and induce apoptosis in breast cancer cells through the PI3K/ AKT /mTOR signaling pathway [A] . AKOSUA KOTAA KWAKYE . 2020

Anti-DR5 monoclonal antibody induces leukemic cell apoptosis

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