Objective To investigate the family burden of patients with severe mental illness. Methods 148 patients with schizophrenia and bipolar disorder were assessed with Family Burden Scale of disease (FBS). Results Family burden broadly exists among those patients with schizophrenia and bipolar disorder, and the burden tends to involve several dimensions, including family relations (51%), home enter-tainment (50%), daily routine (45%), economic burden (43%), mental health of family members (36%) and physical health of family mem-bers (32%). Conclusion Integrated psychological and social intervention should be made to reduce the family burden of patients with schizo-phrenia and bipolar disorder.%目的：探讨重性精神疾病患者的疾病家庭负担。方法采用疾病家庭负担量表(FBS)，对148例符合ICD-10诊断标准的精神分裂症和双相障碍患者的照顾者进行评定。结果精神分裂症和双相障碍患者的疾病家庭负担普遍存在，涉及多个维度。各维度影响达中度以上的分别为家庭关系(51%)、家庭娱乐活动(50%)、家庭日常活动(45%)、经济负担(43%)、家庭成员心理健康(36%)、家庭成员身体健康(32%)。年轻、自费及无个人收入患者的疾病家庭负担更重。结论提示需制定综合的心理社会干预措施，有效减轻照顾者的家庭负担。
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