聚唾液酸（ PSA）经环氧氯丙烷活化后，与透明质酸（ HA）在碱性条件下反应合成了系列PSA-HA接枝聚合物（ P1～P5， PSA与HA质量比分别为1∶1～5∶1），合成率40％～89％，其结构经FT-IR，元素分析和SEM表征。以胰岛素为模型药物，将P2与胰岛素按2∶1（m／m）混合时，包封率和载药率分别为85％和38％，平均粒径为3．2μm。体外释药试验结果表明：P2对胰岛素有一定的体外缓释能力，在6 h内释药89％；在pH 1．2条件下的释药速度大于pH 7．4条件下的释药速度。%The grafted polymers ( P1 ~P5 ) with different mass ratio ( 1 ∶1~1 ∶5 ) of hyaluronic acid with polysialic acid were prepared by reaction of hyaluronic acid ( HA) with activated polysialic acid ( PSA) by epichlorohydrin under alkaline conditions .The synthetic ratio was about 40%~89%.The structures were characterized by FT-IR, elemental analysis and SEM .Taking insulin as a model drug , when the P2 and insulin were mixed by the ratio of 2∶1(m/m), the encapsulation efficiency and drug loading was 85%and 38%, respectively .The average particle size was 3.2 μm.In vitro release test showed a slow-release capability of the embedding insulin by P 2 .The drug release rate reached 89%within 6 h.The drug release rate was faster in pH 1.2 than that in pH 7.4.
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