Objective To study the effect of intravitreal injection of ranibizumab assisted microsurgery on the contents of vascular endothelial growth factors ( VEGF ) and platelet-derived growth factors ( PDGF ) in patients with neovascular glaucoma (NVG).Methods The data of 32 patients(32 eyes) with NVG in our hospital were analyzed retrospectively .All the patients were treated with intravitreal injection of ranibizumab , trabeculectomy and panrentinal photocoagulation .The intraocular pressure ( IOP ) , visual acuity , VEGF and PDGF were compared before and after treatment .The postoperative complications and success rate of treatment were recorded.Results All 32 patients were followed up for (8.57 ±1.69) months.1 week,1 month,3 months and 6 months after trabeculectomy , IOP was significantly lower than that before the injection ( P <0.05).At the end of follow-up,the visual acuity was significantly better than that before injection (P<0.05), and improvement rate of visual acuity was 90.63%.5 d after injection,1 week,1 month,3 months and 6 months after trabeculectomy , the levels of VEGF and PDGF in aqueous humor and vitreous humor were significantly lower than those before injection ( P <0.05 ) .The rate of anterior chamber hemorrhage after trabeculectomy was 6.25%, the rate of encapsulated filtering bleb was 6.25%, and the rate of choroidal detachment was 3.13%.The success rate of surgery was 93.75%at 6 months after surgery .Conclusion The application of intravitreal injection of ranibizumab in trabeculectomy and panrentinal photocoagulation can significantly reduce thelevels of VEGF and PDGF in patients with NVG , reduce IOP and improve visual acuity ,safe and effective .%目的 研究雷珠单抗玻璃体腔注射辅助显微手术治疗对新生血管性青光眼(NVG)患者血管内皮生长因子(VEGF)和血小板衍生生长因子(PDGF)含量的影响.方法 对我院32例(32眼)NVG患者资料进行回顾和分析,所有患者接受玻璃体腔注射雷珠单抗、小梁切除术和全视网膜光凝治疗.比较患者治疗前后眼压、视力、VEGF和PDGF,记录术后并发症和治疗成功率.结果 32例患者随访(8.57±1.69)个月,小梁切除术后1周、1个月、3个月、6个月眼压显著低于注药前,差异具有统计学意义(P<0.05);术后末次随访视力较注药前显著提高(P<0.05),视力提高率90.63%;患者注药后5 d和小梁切除术后1周、1个月、3个月、6个月房水、玻璃体液的VEGF和PDGF水平较注药前显著降低,差异具有统计学意义(P<0.05);小梁切除术后前房出血率6.25%,包裹性滤过泡率6.25%,脉络膜脱落率3.13%;术后6个月手术成功率93.75%.结论 雷珠单抗玻璃体腔注射辅助用于小梁切除术和全视网膜光凝治疗,可显著降低NVG患者VEGF和PDGF水平,降低眼压、提高视力,安全有效.
展开▼
