BACKGROUND:It is widely believed that estrogen and runt-related transcription factor 2 (Runx2) are important regulatory factors in the formation and maintenance of bone. OBJECTIVE:To summarize the recent research progresses and to elaborate the molecular mechanism of interaction between estrogen and Runx2 in osteoblasts. METHODS:“Estrogen”,“runt-related transcription factor 2 (Runx2)”and“osteoblast”were used as search terms in Chinese and English to retrieve PubMed, China Biology Medicine disc, VIP journal ful-text database, WanFang database. Repeatability studies and irrelevant researches were excluded. Total y 62 literatures were obtained with preliminary retrieval and 22 were reserved after further study and analysis. RESULTS AND CONCLUSION:A mass of scientific researchers have found that estrogen and Runx2 do not function independently in osteoblasts but interact with each other through multiple patterns to co-regulate osteoblasts. There exist a complex mechanism of interaction between estrogen and Runx2. Various pathways are involved besides the direct action between estrogen/estrogen receptor and Runx2, such as transforming growth factor-βpathway, Wnt/β-catenin pathway, Fas/Fas ligand pathway and nuclear factor kappa B pathway.% 背景：普遍认为雌激素和成骨特异性转录因子(runt-related transcription factor 2，Runx2)是骨骼形成和维持的重要调控因子。目的：分析总结目前有关成骨细胞中雌激素与 Runx2相互作用的研究进展，综述在成骨细胞中雌激素与Runx2相互作用的分子机制。方法：以“雌激素”、“成骨特异性转录因子”、“成骨细胞”、“Runx-2”、“Estrogen”为检索词，检索PubMed数据库、中国生物医学文献数据库、维普期刊全文数据库、万方数据库有关文章。排除重复性研究及无关研究。计算机初步检索得到62篇文献，经过进一步研读分析，保留22篇进行总结。结果与结论：研究发现，雌激素和Runx2在成骨细胞中并不是孤立的发挥作用，而是通过多种方式相互协同，共同发挥对成骨细胞的调控，作用于骨代谢过程。雌激素与Runx2之间存在的复杂作用机制，除E2/ER与Runx2直接作用外还涉及到许多信号系统，如转化生长因子β信号通路，Wnt/β-连锁蛋白信号通路，Fas/FasL信号通路和核因子κB信号通路等。
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