BACKGROUND:Biomaterials for the treatment of cardiovascular diseases must have anti-thrombotic, anti-biodegradability and anti-infective ability in the blood-contact condition. n OBJECTIVE:To investigate the biocompatibility, blood compatibility and cytocompatibility of new implantable (interfered) polymer material (surface) used in cardiovascular tissue engineering. n METHODS:The PubMed database and Wanfang database were retrieved for the related articles from 1967 to 2012 with the key words of“biocompatibility, lood compatibility, biomedical materials, biomedical polymer n materials”. n RESUTLS AND CONCLUSION:The graft copolymer surface and a block copolymer surfactant that can be used as biological materials were in-depth analyzed though analyzing the design requirements of type, n application, cardiovascular medical devices and implantable soft tissue substitutes of polymeric biomaterials used for cardiovascular medicine. The results showed that the difference between the surface and noumenon wil be reflected on many molecular layers that extended from the surface to the noumenon, while the two main factors of surface energy and molecular motion determined the noumenon/surface behavior including the n noumenon/surface difference and surface phase separation. If the understanding of the noumenon/surface n consisting difference should be taking into consideration, the other determinant should be added too, that was the crystal ization behavior of each competent. If the one of the components contained in the graft copolymer surface and a block copolymer surfactant had higher crystal inity, the other components wil be squeezed out;crystal ization could also hindered the motion and diffusion of molecules, and eventual y, the incompatibility degree of two components of copolymers wil affect the phase separation tendency in the noumenon and n surface layers.
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