首页> 中文期刊> 《中国组织工程研究》 >转化生长因子-β1对瘢痕疙瘩成纤维细胞 SMAD3,7表达的影响

转化生长因子-β1对瘢痕疙瘩成纤维细胞 SMAD3,7表达的影响

         

摘要

AIM: To study the expression of SMAD3 and SMAD7 of transforming growth factor-β 1 ( TGF-β 1) on keloid- derived fibroblasts. METHODS: The expression of SMAD3 (at 1,2,4,24,48 h)and SMAD7(at 0.5 1,1.5, 2,4,24 h) were detected by using methods of Western blot after 500 pmol/L TGF-β 1 were added to the monolayer culture system.RESULTS: The level of SMAD3 were down regulated at 24 h and the SMAD7 were maximum up regulated at 4 h when TGF-β 1 were used.CONCLUSION: TGF-β 1 may down regulate the expression of SMAD3,but up regulate that of SMAD7 .

著录项

  • 来源
    《中国组织工程研究》 |2003年第6期|1006-1007|共2页
  • 作者单位

    Department of Plastic Surgery, Xijing Hospital, Forth Military Medical University, Xi'an 710032, Shaanxi Province,China;

    Department of Plastic Surgery, Xijing Hospital, Forth Military Medical University, Xi'an 710032, Shaanxi Province,China;

    Department of Plastic Surgery, Xijing Hospital, Forth Military Medical University, Xi'an 710032, Shaanxi Province,China;

    Department of Plastic Surgery, Xijing Hospital, Forth Military Medical University, Xi'an 710032, Shaanxi Province,China;

    Department of Plastic Surgery, Xijing Hospital, Forth Military Medical University, Xi'an 710032, Shaanxi Province,China;

    Department of Plastic Surgery, Xijing Hospital, Forth Military Medical University, Xi'an 710032, Shaanxi Province,China;

    Department of Plastic Surgery, Xijing Hospital, Forth Military Medical University, Xi'an 710032, Shaanxi Province,China;

    Department of Plastic Surgery, Xijing Hospital, Forth Military Medical University, Xi'an 710032, Shaanxi Province,China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 外科学;
  • 关键词

    transforming growth factor bata; keloid; fibroblasts;

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