Topical Moltkia coerulea hydroethanolic extract accelerates the repair of excision wound in a rat model

Mohammad Reza Farahpour; Aydin Dilmaghanian; Maisam Faridy; Esmaeil Karashi

首页> 外文期刊>中华创伤杂志（英文版） >Topical Moltkia coerulea hydroethanolic extract accelerates the repair of excision wound in a rat model

【24h】

Topical Moltkia coerulea hydroethanolic extract accelerates the repair of excision wound in a rat model

机译：外用小提子氢乙醇提取物促进大鼠模型切除伤口的修复

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Purpose:To evaluate the effect of a hydroethanolic extract of Moltkia coerulea ointment (MCO) on the healing of excision wound in a rat model.Methods:Circular surgical full thickness excision wound,with 314 mm2 size,was induced in the anterior-dorsal side of each rat.Three different doses of MCO (1％,3％ and 6％) were administrated.On Day 3,7,14 and 21,the tissue was sampled and immune cells,fibroblasts and fibrocytes distribution per one mm2 of wound area,collagen density and re-epithelialization were analyzed.Moreover,the total flavnoid,phenols and anti-oxidant potential of the MCO were evaluated.Ultimately,the percentage of wound contraction in different groups was compared with each other.Results:Hydroethanolic extract of MCO significantly (p ＜ 0.05) increased wound contraction percentage.The animals in medium and high dose MCO-treated groups exhibited remarkably (p ＜ 0.05) higher fibroblast and fibrocyte distribution and significantly (p ＜ 0.05) lower immune cells infiltration.On Day 7 after injury,MCO up-regulated neovascularization in a dose-dependent way.Conclusion:Our data showed that MCO shortened the inflammation phase by provoking the fibroblast proliferation.Moreover,MCO promoted the healing process by up-regulating the angiogenesis and provoking the structural cells proliferation as well as increasing the collagen synthesis,cross-linking,and deposition.

机译：目的：评价蓝藻软膏（MCO）的乙醇提取物对大鼠模型伤口愈合的影响。方法：在前背侧诱发大小为314 mm2的圆形全厚度圆形外科手术伤口分别给予三种不同剂量的MCO（分别为1％，3％和6％）。在第3、7、14和21天取样组织，每1 mm2伤口面积采集免疫细胞，成纤维细胞和纤维细胞分布，分析胶原蛋白的密度和再上皮形成。此外，评估了MCO的总黄酮，酚和抗氧化能力。最后，比较了各组中伤口收缩的百分比。结果：MCO的氢乙醇提取物伤口收缩率显着（p ＜0.05）增加。中，高剂量MCO处理组的动物的成纤维细胞和纤维细胞分布显着（p ＜0.05）高，免疫细胞浸润明显（p ＜0.05）。结论：我们的数据显示，MCO刺激成纤维细胞增殖，从而缩短了炎症期。此外，MCO通过上调血管新生和刺激结构促进了愈合过程，这是损伤后7时MCO剂量依赖性上调新血管形成的过程。细胞增殖以及增加胶原蛋白的合成，交联和沉积。

著录项

来源
《中华创伤杂志（英文版）》 |2016年第2期|97-103|共7页
作者
Mohammad Reza Farahpour; Aydin Dilmaghanian; Maisam Faridy; Esmaeil Karashi;
展开▼
作者单位

Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran;

Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran 14155-6453, Iran;

Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran;

Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran;

展开▼
收录信息中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
原文格式 PDF
正文语种 eng
中图分类
关键词

Topical Moltkia coerulea hydroethanolic extract accelerates the repair of excision wound in a rat model

摘要

著录项

相关主题

期刊订阅