Preparation and characterization of a novel injectable strontium-containing calcium phosphate cement with collagen

Ziqiang Zhou; Dongping Ye; Weiguo Liang; Bin Wang; Zhenzhong Zhu

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Preparation and characterization of a novel injectable strontium-containing calcium phosphate cement with collagen

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Purpose:To develop a novel injectable strontium-containing calcium phosphate cement with collagen.Methods:A novel calcium phosphate bone cement (CPC) was prepared with the addition of strontium element,collagenl,and modified starch;the injectability,solidification time,microstructure,phase composition,compressive strength,anti-collapsibility and histological properties of material were evaluated.Results:The results showed that the material could be injected with an excellent performance;the modified starch significantly improved the anti-washout property of cement;with the liquid to solid ratio of 0.3,the largest compressive strength of cement was obtained (48.0 MPa ± 2.3 MPa);histological examination of repair tissue showed that the bone was repaired after 16 weeks;the degradation of cement was consistent with the new bone growth.Conclusion:A novel injectable collagen-strontium-containing CPC with excellent compressive strength and suitable setting time was prepared,with addition of modified starch.The CPC showed a good antiwashout property and the degradation time of the cement met with the new bone growing.This material is supposed to be used in orthopedic and maxillofacial surgery for bone defects.

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《中华创伤杂志（英文版）》 |2015年第1期|33-38|共6页
作者
Ziqiang Zhou; Dongping Ye; Weiguo Liang; Bin Wang; Zhenzhong Zhu;
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Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University, Guangzhou 510220, China;

Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University, Guangzhou 510220, China;

Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University, Guangzhou 510220, China;

Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University, Guangzhou 510220, China;

Guang Zhou Red Cross Hospital, The Fourth Affiliated Hospital of the Medical College, Jinan University, Guangzhou 510220, China;

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Preparation and characterization of a novel injectable strontium-containing calcium phosphate cement with collagen

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