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首页> 中文期刊> 《中华创伤杂志（英文版）》 >Calcium citrate: a new biomaterial that can enhance bone formation in situ

Calcium citrate: a new biomaterial that can enhance bone formation in situ

         
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摘要

Objective: To investigate the effect of a new biomaterial combining calcium citrate and recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone regeneration in a bone defect rabbit model.Methods: Totally 30 male New Zealand white rabbits were randomly and equally divided into calcium citraterhBMP-2 (CC-rhBMP-2) group and rhBMP-2 only group.Two 10 mm-long and 5 mm-deep bone defects were respectively created in the left and right femoral condyles of the rabbits.Subsequently 5 pellets of calcium citrate (10 mg)combined with rhBMP-2 (2 mg) or rhBMP-2 alone were implanted into the bone defects and compressed with cotton swab.Bone granules were obtained at 2,4 and 6 weeks after procedure and received histological analysis.LSD t-test and a subsequent t-test were adopted for statistical analysis.Results: Histomorphometric analysis revealed newly formed bones,and calcium citrate has been absorbed in the treatment group.The percent of newly formed bone area in femoral condyle in control group and CC-rhBMP-2 group was respectively 31.73％±1.26％ vs 48.21％±2.37％ at 2 weeks; 43.40％±1.65％ vs 57.32％±1.47％ at 4 weeks,and 51.32％±7.80％ vs 66.74％±4.05％ at 6 weeks (P＜0.05 for all).At 2 weeks,mature cancellous bone was observed to be already formed in the treatment group.Conclusion: From this study,it can be concluded that calcium citrate combined with rhBMP-2 signifcantly enhances bone regeneration in bone defects.This synthetic gelatin matrix stimulates formation of new bone and bone marrow in the defect areas by releasing calcium ions.

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  • 来源
    《中华创伤杂志（英文版）》 |2012年第5期|291-296|共6页
  • 作者

    WANG Li-ming; WANG Wei; LI Xiu-cui; PENG Lei; LIN Zhong-qin; X(ü) Hua-zi;

  • 作者单位

    Department of Orthopaedic Surgery,Affiliated Hospital of Binzhou Medical College,Binzhou 256603,Shandong Province,China;

    Department of Orthopaedic Surgery,Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China;

    Department of Respiratory Medicine,Yuying Children's Hospital Affiliated to Wenzhou Medical College,Wenzhou 325000,China;

    Department of Orthopaedic Surgery,Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China;

    Trauma Center of the Affiliated Hospital of Hainan Medical College,Haikou 571100,China;

    Hospital of Integrated Traditional Chinese and Western Medicine of Wenzhou City,Wenzhou 325000,China;

    Department of Orthopaedic Surgery,Second Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,China;

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