Effects of mild hypothermia on patients with lower intracranial pressure following severe brain injury

王维平; 任海军; 池京洋; 徐福林; 全勇

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Effects of mild hypothermia on patients with lower intracranial pressure following severe brain injury

机译：亚低温对重型颅脑损伤后颅内压低的患者的影响

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Objective: To study the effects of mild hypothermia therapy on severe brain-injured patients whose intracranial pressure (ICP) could be maintained below 25 mm Hg.Methods: Forty severe brain-injured patients with ICP below 25 mm Hg were divided randomly into one treatment group (n=20, mild hypothermia therapy) and one control group (n=20, normothermia therapy) to observe the changes of the concentration of excitatory amino acids (glutamate and glycine) and cytokines (interleukin-1β and interleukin-6). Results: There were no significant differences in the daily changes of the concentration of excitatory amino acid and cytokines between two groups. The outcome of two groups had no significant differences. Conclusions: Mild hypothermia has no additional beneficial effects on severe brain-injured patients compared with normothermia therapy if ICP can be maintained below 25 mm Hg by using conventional therapy.

机译：目的：研究轻度低温疗法对颅内压（ICP）可维持在25 mm Hg以下的重度颅脑损伤患者的治疗方法。方法：将40例颅内压在25 mm Hg以下的重度颅脑损伤患者随机分为一种治疗方法两组（n = 20，轻度低温疗法）和一个对照组（n = 20，正常体温疗法）观察兴奋性氨基酸（谷氨酸和甘氨酸）和细胞因子（白介素-1β和白介素-6）浓度的变化。结果：两组患者每日兴奋性氨基酸浓度和细胞因子变化无明显差异。两组的结果无显着差异。结论：如果使用常规疗法可以将ICP维持在25 mm Hg以下，那么与正常体温疗法相比，轻度低温对重度脑损伤患者没有其他好处。

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来源
《中华创伤杂志（英文版）》 |2005年第1期|54-56|共3页
作者
王维平; 任海军; 池京洋; 徐福林; 全勇;
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作者单位

Department of Neurosurgery, Minhang Hospital of Ruijin Hospital Groups, Shanghai 201100, China;

Department of Neurosurgery, The 2nd Hospital of Lanzhou Medical College;

Department of Neurosurgery, Minhang Hospital of Ruijin Hospital Groups, Shanghai 201100, China;

Department of Neurosurgery, Minhang Hospital of Ruijin Hospital Groups, Shanghai 201100, China;

Department of Neurosurgery, Minhang Hospital of Ruijin Hospital Groups, Shanghai 201100, China;

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正文语种 chi
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关键词
Brain injury; Intracranial pressure; Hypothermia;

机译：脑损伤;颅内压;体温过低;

Effects of mild hypothermia on patients with lower intracranial pressure following severe brain injury

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