Association of HIF- expression and cell apoptosis after traumatic brain injury in the rat

首页> 中文期刊> 《中华创伤杂志（英文版）》 >Association of HIF- expression and cell apoptosis after traumatic brain injury in the rat

Association of HIF- expression and cell apoptosis after traumatic brain injury in the rat

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Objective: To explore the expression of hypoxia inducible factor-1α (HIF-1~) and the correlation between HIF-1α and apoptosis after traumatic brain injury.Methods: Using experimental traumatic brain injury in the rats, the expression of HIF-1α was studied by immunohisto-chemistry in cerebral tissue, apoptotic cell death was evaluated with TUNEL (transferase-mediated XdUTP nick end labeling ), and double-labeled immunohistochemistry and TUNEL methods were used to investigate the relationship between HIF-1α and apoptosis.Results: There was remarkable difference in the expression of HIF-1α between the experimental groups and the control groups (P ＜ 0.01), in the experimental groups,the expression of HIF-1α at 48 hours was highest; the evidence of apoptotic cell death after experimental traumatic brain injury was found by TUNEL; the apoptotic percentage increased or decreased according to the changes of the positive expression of HIF-1α (r = 0.99).Conclusions: The results suggest that secondary brain ischemia plays a crucial role in apoptotic cell death after traumatic brain injury; HIF-1α can prompt apoptotic cell death after experimental traumatic brain injury.u0000e expres

著录项

来源
《中华创伤杂志（英文版）》 |2001年第4期|218-221|共4页
作者

展开▼
作者单位

Department of Neurosurgery, Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China;

Department of Neurosurgery, West China Medical University, Chengdu 610041, China;

Department of Neurosurgery, West China Medical University, Chengdu 610041, China;

Department of Neurosurgery, West China Medical University, Chengdu 610041, China;

Department of Neurosurgery, West China Medical University, Chengdu 610041, China;

展开▼
原文格式 PDF
正文语种 chi
中图分类外科学;
关键词
Brain injuries; Apoptosis; Hypoxiainducible factor-1α;

机译：脑损伤;细胞凋亡;缺氧诱导因子-1α;

Association of HIF- expression and cell apoptosis after traumatic brain injury in the rat

摘要

著录项

相关主题

期刊订阅