Objective To reveal the ultrasonographic features and its relative pathologic basis of patients with neuroendocrine cancer of the breast.Methods We reviewed clinical data and ultrasonographic findings on 12 cases of neuroendocrine breast cancer(NEBC),in comparison to the postoperative pathology findings.Results Based on the morphologic features,these 12 cases were categorized into 9 solid types and 3 small cell types.Solid type had expansive and infiltrative growth with a visible edge of "pseudocapsule" formed by fibrous connective tissue surrounding the cancer nests.Small cell type had a high-grade malignancy with markedly atypical cells and infiltrative growth.NEBC presented a hypoechoic solid lesion(100％),no posterior attenuation(100％),indistinct or micro lobulated margins or atypical spiculated sign (85.0 ％),irregular shape(76.9 ％),maximum diameter of lesion ＜ 2 cm (61.5 ％),clear border (61.5 ％),heterogeneous hypoechoic(61.5 ％),internal blood flow of grade Ⅱ-Ⅲ (55.9 ％).According to pathology results,the ultrasonic coincidence rate of NEBC was 66.7 ％ (8/12).Conclusions Solid types are the principal type of NEBC,it can be easily misdiagnosed as benign lesions if appeared as small size and clear border without typical spiculated sign.%目的 探讨乳腺神经内分泌癌(NEBC)的超声表现及与病理组织学的关系.方法 回顾经病理证实的12例NEBC的临床及超声表现,并与术后病理进行对照分析.结果 12例NEBC组织学类型:实性型9例(组织学Ⅰ级3例,Ⅱ级6例),膨胀性生长为主,癌巢边缘可见纤维结缔组织包绕形成“假包膜”;小细胞型3例(组织学Ⅲ级),癌巢呈蟹足状浸润且周围间质反应明显,两亚型均细胞丰富,间质成分少.声像图表现多为实性低回声肿块(100％),后方回声无衰减(100％),边缘模糊、细分叶或不典型的成角、毛刺(85.0％),形态不规则(76.9％),病灶最大径≤2 cm (61.5％),边界清晰(61.5％),内部回声不均匀(61.5％),Ⅱ～Ⅲ级血流信号(55.9％).超声定性诊断与病理符合率为66.7％ (8/12).结论 NEBC的超声表现缺乏特征性,组织学以实性型为主,当病灶较小、边界清晰、边缘成角或毛刺征不典型时易误诊为良性.
展开▼
