Objective To compare the clinical application of peripherally inserted central catheter (PICC) via basilic vein and internal jugular vein under guidance of color Doppler ultrasonography (CDU). Methods Patients with malignant tumors were randomly divided into basilic vein PICC group (30 cases) and internal jugular vein PICC group (30 cases). One-time success rate of puncture catheter, one-time success rate and life quality data were analyzed and compared between two groups. Results One-time success rate and one-time success rate of catheter in the basilic vein PICC group were 100%, while in the internal jugular vein PICC group one-time puncture success rate and one-time catheter success rate was 86.68% and 83.33%, respectively. There were statistically significant differences between the two groups (P <0. 001). The quality of life for patients in basilic vein PICC group was better than that in the internal jugular vein PICC (P <0. 001). Conclusion The basilic vein puncture PICC under the guidance of CDU has higher accuracy, security and puncture success rate, which worth for clinical application.% 目的比较彩色超声引导下经贵要静脉和经颈内静脉入路实施经外周静脉穿刺中心静脉置管术（PICC）的临床应用价值。方法60例在彩超引导下进行 PICC 的恶性肿瘤患者随机分为经贵要静脉组（30例）和经颈内静脉组（30例），对比其一次性穿刺成功率、一次性置管成功率和生活质量。结果经贵要静脉入路 PICC 组一次性穿刺成功率及一次性置管成功率均为100%，而经颈内静脉入路组一次性穿刺成功率为86.68%，一次性置管成功率为83.33%，两组比较差异有统计学意义（P <0.001）；两组置管后生活质量比较差异有统计学意义（P <0.001）。结论在彩超引导下的经贵要静脉入路行 PICC 的准确性、安全性及成功率高，值得临床推广应用。
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