目的 研究再次取卵+体外受精-胚胎移植(IVF-ET)女性患者的焦虑抑郁发生情况,探讨心理干预对第二次取卵患者的心理状态、妊娠结局的影响.方法 将2014年1月至2015年6月在同济大学附属第一妇婴保健院生殖医学中心再次取卵+IVF-ET的女性患者随机分为实验组(187例)和对照组(181例),实验组在常规临床护理的基础上,额外给予特殊的心理干预,对照组仅给予常规临床护理,通过焦虑自评量表(SAS)和抑郁自评量表(SDS)调查两组患者的焦虑抑郁情况,结果 实验组患者的SAS评分、SDS评分均显著低于对照组(t值分别为-2.084、-2.239,均P<0.05).实验组患者的妊娠率显著高于对照组(χ2=3.588,P<0.05),两组获卵率、受精率、优胚率均无显著性差异(χ2值分别为2.149、1.178、2.897,均P>0.05).结论 再次行取卵+IVF-ET治疗的患者易产生焦虑抑郁心理,通过有效的心理干预,可以改善这些患者的心理状态和妊娠结局.%Objective To study the incidence of anxiety and depression in patients accepting second cycle of oocyte retrieval and in vitro fertilization-embryo transfer (IVF-ET) and to investigate the effects of psychological nursing on psychological state and pregnancy outcomes in second IVF-ET cycle.Methods Female patients implemented with oocyte retrieval and IVF-ET for second time in reproductive medicine center of First Maternity and Infant Hospital in Tongji University from January 2014 to June 2015 were divided into experimental group (187 cases) and control group (181 cases) randomly.Patients in the experimental group were given additional mental intervention and psychological nursing on basis of routine clinical care, while patients in the control group only received routine clinical care.Anxiety and depression degree in two groups were investigated by Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS).Results Scores of SAS and SDS in the experimental group were obviously lower than those in the control group (t value was-2.084, and-2.239, respectively, both P<0.05).Pregnancy rate of the experimental group was significantly higher than that of the control group (χ2=3.588, P<0.05).There was no significant difference in oocyte retrieval rate, fertilization rate and good quality embryo rate between two groups (χ2 value was 2.149, 1.178 and 2.897, respectively, all P>0.05).Conclusion Patients accepting second oocyte retrieval and IVF-ET cycle are easy to suffer anxiety and depressive disorder.Effective mental intervention and psychological nursing are able to improve psychological status and pregnancy outcomes.
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