目的：探讨支原体肺炎患儿心血管系统损害的临床特点及相关危险因素。方法回顾性分析自2013年1月至2014年6月期间宁波市鄞州区茅山社区卫生服务中心收治的189例支原体肺炎患儿的临床资料，采集患血管系统损害的临床表现，并对发生心血管系统损害的相关危险因素进行单因素以及多因素Logistic回归分析。结果在189例肺炎支原体感染患儿中，共有42例并发肺外心血管系统损害，发病率为22.2%；多因素Logistic回归分析提示：年龄(OR=2.452)、热程(OR=1.337)、C-反应蛋白(OR=1.563)、发热程度(OR=1.310)、大环内酯类抗生素应用起始时间(OR=2.452)与支原体肺炎患儿肺外心血管系统损害均呈正相关(均P<0.05)，而CD4+/CD8+比值升高(OR=0.679)则为保护性因素(P<0.05)。结论年龄、热程、高C-反应蛋白、发热程度、大环内酯类抗生素应用起始时间及低血清CD4+/CD8+比值是肺炎支原体感染患儿肺外心血管系统损害的高危因素，临床应根据这些高危因素制定防止措施以改善患儿的预后。%Objective To investigate the clinical characteristics of cardiovascular system damage in children with mycoplasma pneumoniae ( MP) and related risk factors. Methods A retrospective analysis was conducted on the clinical data of 189 children with MP treated during the period of January 2013 to June 2014 in Ningbo Yinzhou District Maoshan Community Health Service Center, and clinical manifestations of cardiovascular system damage were collected. Related risk factors of cardiovascular system damage were analyzed by univariate and multivariate Logistic regression analysis. Results Of 189 cases with MP, 42 children were complicated with cardiovascular system damage, and the incidence was 22. 2%. Multivariate Logistic regression analysis showed that age (OR=2. 452), course of fever (OR=1. 337), CRP (OR=1. 563), degree of fever (OR=1. 310) and starting time of macrolides antibiotics application (OR=2. 452) were positively correlated with cardiovascular system damage (all P <0. 05), but CD4 + /CD8 +(OR =0. 679)inereasing was protective factors(P <0. 05). Conclusion Age, course of fever, CRP, degree of fever, starting time of macrolides antibiotics application and low CD4 + /CD8 +are high risk factors of cardiovascular system damage in children with MP. Clinical measures should be taken to improve prognosis of patient children against these risk factors.
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