Objective To explore whether insulin resistance (IR) increases maternal recurrent spontaneous abortion (RSA) by meta-analysis of published articles at home and abroad with randomized case-control study. Methods Literatures on case-control study on relationship between RSA and IR published during the period of January 1996 to January 2014 were retrieved in PubMed, Embase, Springer link, Chinese Biomedical Literature Database with computer and other journals by hand, and they were screened with set standard and grouped for analysis. Meta-analysis was conducted for the relationship between them. Results Totally 6 articles were selected into the study. There were 432 pregnant women in RSA group and 383 cases in control group ( no abnormal pregnancy history was found) . Under the condition of no significant difference in fasting glucose level, fasting insulin value elevated and isletβ-cell function was impaired more severely in RSA group. IR index was higher in RSA group, which suggested that most of cases with IR index higher than 4. 5 were from RSA group, and the difference was significant (OR=3. 16, 95%CI:1. 7-6. 8,I2 =1. 157,P<0. 05). Conclusion IR is correlated with RSA among pregnant women, and it might be one cause of RSA.%目的：对国内外发表的随机病例对照研究文章进行Meta分析,力图探明胰岛素抵抗( IR)是否增加孕产妇复发性流产( RSA)的风险。方法使用计算机检索PubMed、Embase、Springer Link、中国生物医学文献数据库等数据库及手工检索相关期刊内自1996年1月至2014年1月之间发表的有关于RSA与IR关系的病例对照研究类国内外文献,按既定标准筛选后对入组文献进行质量评分,并使用Meta分析探究两者间关系。结果分析中共计6篇国内外文献选入研究范围,RSA组共计432例孕产妇,对照组共计383例(均未见不良孕产史)。分析提示,两组孕产妇在空腹血糖水平差异无统计学意义的前提下,出现了RSA组患者空腹胰岛素数值相对升高及RSA组患者的胰岛β细胞功能受损较对照组严重；且RSA组患者的IR指数较对照组高,即IR指数>4.5的患者大多来自RSA组,差异具有统计学意义(OR=3.16,95%CI为1.7~6.8,I2=1.157,P<0.05)。结论 IR与RSA间存在一定相关性,其可能为RSA的原因之一。
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