Objective To study the correlation between maternal hypothyroidism at first and second trimester with age. Methods Four hundred pregnant women admitted in Maternal and Child Health Hospital of Nanchuan District in Chongqing were divided into first trimester group (≤12 weeks) and second trimester group (13-27 weeks) according to gestational age. Thyroid stimulating hormone ( TSH) and free thyroxine 4 (FT4) levels were measured by chemiluminescence method. The age of 30 was taken as critical value, and TSH level, FT4 level, and the incidence of hypothyroidism and subclinical hypothyroidism were compared between advanced age pregnant women(≥30) and young pregnant women( <30). Results The were no significant differences in serum levels of TSH and FT4 between advanced age pregnant women and young pregnant women in first trimester group (t value was 1. 03 and 1. 09, respectively, both P>0. 05) and second trimester group (t value was 1. 18 and 1. 21, respectively, both P>0. 05). The incidence of hypothyroidism was 0. 5% and 2. 0% in first trimester group and second trimester group, respectively, and there was no significant difference in the incidence of hypothyroidism between advanced age pregnant women and young pregnant women in both groups (χ2 value was 1. 39 and 1. 12, respectively, both P>0. 05). In first trimester group there was no significant difference in the incidence of subclinical hypothyroidism between advanced age pregnant women and young pregnant women (χ2 =1. 74,P>0. 05), but the incidence of subclinical hypothyroidism of advanced age pregnant women was significantly higher than that of young pregnant women in second trimester group (χ2 =3. 83, P<0. 05). Conclusion The hypothyroidism of pregnant women is not significantly correlated with age at first trimester, but the incidence of it increases with age increasing in second trimester. Age factor may be related with gestational hypothyroidism, so much attention should be paid on it.%目的：研究孕早期和孕中期孕妇甲状腺功能减退与年龄因素的相关性。方法将重庆市南川区妇幼保健院收治的400例孕妇按照孕龄分为孕早期组(≤12周)和孕中期组(13~27周),采用化学发光法进行促甲状腺激素(TSH)和游离甲状腺素4(FT4)水平的测定,以30岁为临界值,对比高龄(≥30岁)孕妇与低龄(<30岁)孕妇的TSH水平、FT4水平、甲状腺功能减退和亚临床甲状腺功能减退的发生率。结果孕早期组高龄孕妇和低龄孕妇的血清TSH、FT4水平比较均无显著性差异( t值分别为1.03、1.09,均P>0.05),孕中期组高龄孕妇和低龄孕妇的血清TSH、FT4水平比较均无显著性差异(t值分别为1.18、1.21,均P>0.05)。孕早期组和孕中期组的甲减发生率分别为0.5%和2.0%,孕早期和孕中期组高龄孕妇与低龄孕妇比较,甲减发生率无显著性差异(χ2值分别为1.39、1.12,均P>0.05)。孕早期孕妇中高龄孕妇与低龄孕妇比较,亚临床甲减发生率无显著性差异(χ2=1.74,P>0.05),但孕中期孕妇中高龄孕妇亚临床甲减发生率显著高于低龄孕妇(χ2=3.83,P<0.05)。结论孕早期孕妇的甲状腺功能减退情况与年龄并无显著相关性,而孕中期孕妇的甲状腺功能减退发生率随着年龄增加而上升,年龄因素可能与妊娠期甲状腺功能减退有所相关,需要引起重视。
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