Objective To investigate the expression levels of regulated upon activation normal T cell expressed and secreted ( RANTES) in serum and eutopic/ectopic endometrium in women with endometriosis and its clinical significance. Methods 89 Patients with endometriosis were selected as study objects ( observation group) , and 60 women with normal pelvic structure who underwent laparoscopic surgery for IUD extract in First People’ s Hospital of Jiangxia District in the same period were recruited in control group. Clinical data of all cases were collected. RANTES levels in serum and eutopic/ectopic endometrium of two groups were detected and analyzed. Results The serum RANTES level in the observation group was significant higher than that in the control group (t=3. 06,P<0. 05), and that of patients inⅠ-Ⅱstage and Ⅲ-Ⅳ stage was significantly higher than that of the control group ( t value was 2. 68 and 4. 13, respectively, both P<0. 05). The serum RANTES levels in eutopic endometrium and ectopic endometrium were significantly higher than normal endometrium (t value was 3. 26 and 4. 05, respectively, both P<0. 05), and those in eutopic endometrium of patients inⅠ-Ⅱstage andⅢ-Ⅳstage were higher than in normal endometrium (t value was 3. 15 and 4. 23, respectively, both P<0. 05). The serum RANTES level was positively related with pelvic adhesion score (r=3. 986, P<0. 05), but not significantly correlated with dysmenorrhea score (r=0. 287,P>0. 05). Conclusion RANTES may play an important role in the pathogenesis of endometriosis.%目的：探讨调节活化正常T细胞表达与分泌的趋化因子( RANTES)在子宫内膜异位症患者血清、在位/异位内膜组织中的表达水平及临床意义。方法选择确诊为盆腔子宫内膜异位症的患者89例为研究对象(观察组),以武汉市江夏区第一人民医院妇产科同期取宫内节育器且盆腔结构正常的60例女性为对照组,收集所有患者临床资料。采用酶联免疫吸附( ELISA)法检测血清、异位/在位内膜RANTES水平,并进行分析。结果观察组血清RANTES水平显著高于对照组(t=3.06,P<0.05),且观察组中Ⅰ~Ⅱ期、Ⅲ~Ⅳ期血清RANTES水平均显著高于对照组(t值分别为2.68、4.13,均P<0.05)。在位内膜组和异位内膜组RANTES水平均较正常内膜组显著升高(t值分别为3.26、4.05,均P<0.05)；Ⅰ~Ⅱ期、Ⅲ~Ⅳ期异位内膜组RANTES水平均较Ⅰ~Ⅱ期、Ⅲ~Ⅳ期在位内膜组显著升高(t值分别为3.15、4.23,均P<0.05)。子宫内膜异位症血清RANTES水平与盆腔粘连范围评分呈显著正相关(r=3.986,P<0.05),与痛经评分无显著相关性(r=0.287,P>0.05)。结论 RANTES可能在子宫内膜异位症的发生发展中起重要作用。
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