Objective To understand the incidence of intrahepatic cholestasis of pregnancy (ICP) in Wuhan and explore the influencing factors and the influence on maternal and perinatal outcomes .Methods Retrospective analysis was conducted on the incidence of ICP in 1 206 cases.Results There were statistical differences in the detection values of alanine aminotrans -ferase, aspartate amin-otransferase, total bile acid, total bilirubin, direct bilirubin, free triiodothyroxine, free thyroxine and thyroid stimulating hormone between ICP group and control group(t value was 8.369, 7.250, 2.034, 3.015, 2.122, 1.382, 2.746 and 2.831, respectively, all P<0.05).Comparison between ICP group and control group showed that the difference in the incidence of fetal distress , premature delivery , meconium stained amniotic fluid and neonatal asphyxia was significant (χ2 value was 793.998, 22.342, 47.641 and 5.916, respectively, all P<0.05). Conclusion Monitoring should be strengthened during pregnancy and early diagnosis of ICP should be made .Cesarean section indications should be loosened appropriately and pregnancy be terminated timely so as to reduce the morbidity and mortality of perinatal as far as possible .%目的了解武汉地区人群妊娠期肝内胆汁淤积症的发病情况，探讨其影响因素及对母体和围生儿的影响。方法采取回顾性分析方法，对1206例妊娠期肝内胆汁淤积症患者的发病情况进行分析。结果妊娠期肝内胆汁淤积症组与对照组比较，丙氨酸氨基转移酶、天冬氨酸氨基转移酶、总胆汁酸、总胆红素、直接胆红素、血清游离甲状腺素、血清游离三碘甲腺原氨酸及促甲状腺素检测值差异均有统计学意义（ t值分别为8．369、7．250、2．034、3．015、2．122、1．382、2．746、2．831，均P＜0．05）。妊娠期肝内胆汁淤积症组与对照组比较，胎儿宫内窘迫、早产、羊水粪染及新生儿窒息发生率的差异均有统计学意义（χ2值分别为793．998、22．342、47．641、5．916，均P＜0．05）。结论应加强孕期监护，早期诊断妊娠期肝内胆汁淤积症，酌情放宽剖宫产指征，适时终止妊娠，尽可能降低围生儿的患病率和病死率。
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