To explore the influence of neoadjuvant chemotherapy( NACT ) on operative effect and sexual life quality of patients with cervical cancer at stage Ⅰbt ~ Ⅱb. Methods Sixty-six patients were divided into two groups, chemotherapeutic surgery group with NACT ( 37 cases ) and direct surgery group ( 29 cases ), and they were followed up for one year after treatment. Operating time, intraoperative blood loss, number of dissected lymph node, lymph node positive rate, bladder rehabilitation and quality of sexual life were compared between two groups. Results Postoperative pathological vaginal margins and parametrial resection margins of the patients showed that they were free of cancer residue. The differences in operating time, number of dissected lymph node, lymph node positive rate and bladder rehabilitation between two groups were not statistically significant ( P >0. 05 ), but the volume of bleeding during operation was lower in chemotherapeutic surgery group and there was significant difference ( t = 2. 01 ,P < 0. 05 ). After 6 months of treatment, the degree of sexual desire reducing and vaginal dryness and pain of patients in chemotherapeutic surgery group were significantly higher than those of direct surgery group( t was 4. 01 and 4. 00, respectively, both P < 0. 05 ). But after 12 months of treatment, there was no significant difference in quality of sexual life between two groups ( sexual desire reducing t =0.06, sexual pleasure reducing t =0.47, vaginal dryness and pain t = 0. 04, all P > 0. 05 ). Conclusion NACT before surgery dose not increase operating time or lymph node positive rate and it can reduce the volume of bleeding during operation as well, but the quality of sexual life will be affected in a short period of time.%目的 探讨新辅助化疗对Ⅰb ～Ⅱb期宫颈癌患者手术疗效及性生活质量的影响.方法 根据术前是否行新辅助化疗将66例患者分为化疗手术组(37例)与直接手术组(29例),治疗结束后随访1年,比较两组的手术时间、术中出血量、清扫淋巴结数目、淋巴结阳性率、术后膀胱恢复时间及性生活质量.结果 患者术后病理阴道切缘及宫旁切缘均无癌残留,2组患者在手术时间、清扫淋巴结数目、淋巴结阳性率及术后膀胱恢复时间上差异无统计学意义(P＞0.05),化疗手术组术中出血量低于直接手术组,差异有统计学意义(t=2.01,P＜0.05).化疗手术组在治疗后6个月性欲望降低程度(t=4.01),阴道干涩疼痛感(t=4.00)明显高于直接手术组,P＜0.05;但治疗后12个月2组间性生活质量差别无统计学意义(性欲望降低程度t=0.06,性愉悦度降低t=0.47,阴道干涩疼痛感t=0.04,P＞0.05).结论 宫颈癌术前新辅助化疗并不影响手术时间、淋巴结阳性率,可减少术中出血量,但在短时间内影响性生活质量.
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