目的 探讨中国人群血管紧张素Ⅱ-1型受体(angiotensin Ⅱ type 1 receptor,AT1R)基因多态性与妊娠期高血压疾病发病的相关性.方法 计算机检索中国期刊全文数据库、万方数据库、重庆维普数据库以及Pubmed数据库,检索时间为从建库至2012年1月.按纳入、排除标准选择纳入有关中国人群AT1R A1166C基因多态性与妊娠期高血压疾病相关性的病例对照研究,评价纳入研究质量,并采用RevMan 5.1和Stata 11.0软件进行分析.结果 共纳入11篇文献,病例组共计862例,对照组共计1 142例.AT1R基因1166位点携带变异基因型(AC型+CC型)的孕妇发生妊娠期高血压疾病的危险增加,合并OR值为2.11,95%CI为1.29~3.46.AT1R基因1166位点携带C等位基因的孕妇发生妊娠期高血压疾病的危险增加,合并OR值为2.02,95%CI为1.29~3.17.结论 AT1R A1166C基因多态性可能与中国人群妊娠期高血压疾病相关,C等位基因可能为妊娠期高血压疾病的致病基因.%Objective To investigate the correlation between angiotensin II type 1 receptor ( AT1R ) gene polymorphism and hypertensive disorder complicating pregnancy ( HDCP ) in Chinese population. Methods CNKI, Wanfang database, VIP, and Pubmed were electronically searched from the very beginning to January 2012. Case-control studies of A1166C gene polymorphism of ATI R and HDCP in Chinese population were included according to inclusion criteria, and the quality of included studies was assessed. The data was quantitatively analyzed with RevMan 5. 1 and Stata 11.0 software. Results A total of 11 studies involving 862 patients and 1 142 healthy individuals were included. Pregnant women with mutant genotype AC + CC at 1166 locus of AT1R gene had higher onset risk of HDCP (OR = 2.11, 95%CI: 1.29-3.46), and the allele C carriers also had higher onset risk of HDCP ( OR = 2.02, 95% CI: 1.29-3.17). Conclusion The A1166C polymorphism of AT1R gene might be associated with HDCP in Chinese population, and the allele C might be a risk factor.
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