Melatonin ( MLT), as a kind of neuroendocrine hormone, which is mainly secreted by pineal body, plays broad and important physiological roles in human body. MLT is synthesized mainly through retina-pineal body pathway, and induces different kinds of physiological biochemical reaction of downstream target organs. Receptors of MLT exist widely in brain and sexal glands. A series of research showed that MLT has a strong inhibiting effect on reproduction of female and male animals, thus it can regulate reproduction activity of the animals. This article reviewed application of MLT in reproductive medicine and clinic and prowess in the study.%褪黑素作为一种主要由松果腺分泌的神经内分泌激素,在生物体内具有广泛而又重要的生理作用.褪黑素主要通过视网膜-松果体通路合成,并能引起下游的多种生理生化反应.褪黑素的受体广泛分布于大脑组织和性腺中,其对雌雄动物的生殖系统均具有显著的抑制作用,从而实现对生殖功能的调控.该文对褪黑素在生殖医学和临床应用中的作用及研究进展作以综述,以期对褪黑素的深入探讨有所裨益.
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