Objective To investigate risk factors of fetal growth restriction (FGR) complicated with preeclampsia and perinatal outcomes.Methods The clinical data of 186 pregnant women with FGR complicated with/without preeclampsia were retrospectively analyzed. They were divided into two groups according to whether FGR was complicated with preeclampsia or not: FGR complicated with preeclampsia group ( n = 32 ) and FGR not complicated with preeclarnpsia group ( n = 154 ). Results In FGR complicated with preeclampsia group, the gastational age of the neonates was significantly younger than that of neonates born by those pregaant women with FGR not complicated with preeclampsia (t = 3. 695, P ＜0.001 ) ,and perinatal body weight was significantly lower than that born by pregnant women with FGR not complicated with preeclampsia ( t = 3. 950, P ＜ 0.001 ). The incidence rate of neonatal asphyxia in FGR complicated with preeclampsia group was higher than that in FGR not complicated with preeclampsia group (X2 = 6. 124, P = 0. 013 ). The gestational weeks when FGR was diagnozed in FGR complicated with preeclampsia group was earlier than that in FGR not complicated with preeclampsia group ( Wald =6. 513, P = 0. 012 ). Conclusion Early-onset FGR may bo a high-risk factor that the pregnant woman with FGR would develop preoclampsia. The outcomes of perinatal infants born by those pregnant women with FGR complicated with preeclampsia are generally poorer. So some measures should be adopted in order to prevent actively, identify early and intervene timely FGR complicated with preeclampsia.%目的 探讨发生胎儿生长受限后并发子痫前期的高危因素及围产儿结局,了解其临床特征.方法 对186例胎儿生长受限的患者进行回顾性分析.根据发生胎儿生长受限后有无并发子痫前期分为:发生胎儿生长受限后并发子痫前期组(32例)和胎儿生长受限未合并子痫前期组(154例)进行比较.结果 发生胎儿生长受限后并发子痫前期组的分娩孕周显著早于胎儿生长受限未合并子痫前期组(t=3.695,P<0.001);围产儿体重显著低于未合并子痫前期组(t=3.950,P<0.001);新生儿窒息的发病率高于未合并子痫前期组(χ2=6.124,P=0.013);诊断胎儿生长受限的孕周早于未合并子痫前期组(Wald=6.513,P=0.012).结论 早发型胎儿生长受限可能是胎儿生长受限孕妇易并发子痫前期的危险因素,发生胎儿生长受限后并发子痫前期的围产儿预后较差,因此应积极预防,早期发现,及时干预.
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