分娩启动是子宫由相对静止进入活跃状态的复杂过程,子宫平滑肌是其效应的靶器官,但其收缩机制尚未完全阐明,因而限制了临床处理及相关药物的开发.该文从子宫平滑肌细胞内收缩相关装置、经典电生理机制、细胞内的信号转导、钙敏感性理论、分娩启动相关膜蛋白的功能及变化等方面作以综述,以期了解调节子宫平滑肌收缩可能的分子机理,从而完善对妊娠子宫正常生理过程和常见病理状态的整体认识,也有助于对分娩、早产、产后出血等临床事件的预测和处理.%Onset of labor is a complex process of myometrial activation fiom quiescent pregnant state to active contractile state. The uterine smooth muscle plays an important role in this process, but the mechanism by which contraction is regulated is not fully clear so far.The goal of this review is to provide an overview of the molecular mechanism by which uterine contractility might be regulated, including the contractile apparatus, electrophysiology of uterine nyocytes, mechanism of calcium sensitization, contraction-associated proteins etc., thus provides better understanding of parturition, preterm labor and postpartum hemorrhage.
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