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首页> 中文期刊> 《中华医学杂志（英文版）》 >Comparison of tamsulosin with extracorporeal shock wave lithotripsy in treating distal ureteral stones

Comparison of tamsulosin with extracorporeal shock wave lithotripsy in treating distal ureteral stones

         
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摘要

Background Tamsulosin,an alpha-1 receptor antagonist,has been demonstrated effective in promoting distal ureteral stone passage and in reducing pain associated with stone expulsion.This study aimed to evaluate the effect of tamsulosin in comparison with nifedipine and extracerporeal shock wave lithotripsy (ESWL) on the expulsion rate of distal ureteral stones at different sizes.Methods We assigned 314 patients to three categories:Ⅰ,the stone with maximal diameter of 4.0-5.9 mm;Ⅱ,6.0-7.9mm,and Ⅲ,8.0-9.9 mm.Patients in each category were randomly subdivided into three treatment subgroups:group A (nifedipine group),group B (tamsulosin group),and group C (ESWL group).Stone-free rate and the dose of analgesics were recorded weekly during the 4-week follow-up period.Results Three hundred and three patients completed the study.The results showed that nifedipine and tamsulosin treatments promoted a small (4-8 mm,categories Ⅰ and Ⅱ) stone expulsive rate that was comparable with ESWL treatment.Nonetheless,when the stone diameter was 8.0-9.9 mm,ESWL showed a greater stone free rate than nifedipine and tamsulosin treatments;no significant difference existed between the latter two therapies.Although the ESWL treatment group required the least analgesics,tamsulosin treatments required less pain medication than nifedipine (P ＜0.05).Conclusions Tamsulosin treatment is recommended for patients with the stone diameter smaller than 8 mm because of its feasibility,effectiveness and safety.ESWL is more appropriate than tamsulosin therapy for the patients whose stones are larger than 8 mm.

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  • 来源
    《中华医学杂志（英文版）》 |2009年第7期|798-801|共4页
  • 作者

    ZHANG Meng-yuan; DING Sen-tai; L(U) Jia-ju; LUE Yan-he; ZHANG Hui; XIA Qing-hua;

  • 作者单位

    Department of Urology,Provincial Hospital Affiliated to Shandong University,Jinan,Shandong 250021,China;

    Department of Urology,Provincial Hospital Affiliated to Shandong University,Jinan,Shandong 250021,China;

    Department of Urology,Provincial Hospital Affiliated to Shandong University,Jinan,Shandong 250021,China;

    Division of Endocrinology,Department of Medicine,Los Angeles Medical Center and Los Angeles Biomedical Research Institute at Harbor University of California,Los Angeles Medical Center,Torrance,California,90502,USA;

    Department of Urology,Provincial Hospital Affiliated to Shandong University,Jinan,Shandong 250021,China;

    Department of Urology,Provincial Hospital Affiliated to Shandong University,Jinan,Shandong 250021,China;

  • 原文格式 PDF
  • 正文语种 chi
  • 中图分类 内科学;
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