Effects of magnesium sulfate on neuron apoptosis and expression of caspase-3,bax and bcl-2 after cerebral ischemia-reperfusion injury

周海燕; 马岳峰; 周益锋; 柳子明; 王凯; 陈钢

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Effects of magnesium sulfate on neuron apoptosis and expression of caspase-3,bax and bcl-2 after cerebral ischemia-reperfusion injury

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Objective To investigate the effects of magnesium sulfate on neuron apoptosis and the expressions of caspase-3,bax and bcl-2 after cerebral ischemia-reperfusion injury. Methods Thirty-six gerbils were randomly divided into three groups: Sham-operation group (So, n=12), ischemia-reperfusion group (I-R, n=12) and magnesium sulfate group (Ms, n=12). The neuron apoptosis was detected by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-fluorescence nick end labeling (TUNEL stain), and the protein expressions of caspase-3, bax and bcl-2 were detected by immunohistochemisty stain.Results Apoptotic neurons and the expressions of caspase-3 and bax were significantly increased in I-R and Ms groups, compared with those in So group. Apoptotic neurons and the expressions of bax and caspase-3 in Ms group were significantly less than those in I-R group. There was no significant difference in the expression of bcl-2 among three groups.Conclusions Magnesium sulfate decreases neuron apoptosis after cerebral ischemia-reperfusion injury, which may be related with the suppressed expressions of caspase-3 and bax.

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《中华医学杂志（英文版）》 |2003年第10期|1532-1534|共3页
作者
周海燕; 马岳峰; 周益锋; 柳子明; 王凯; 陈钢;
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Department of Anesthesiology, the Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China;

Department of Emergency, the Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China;

Department of Anesthesiology, the Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China;

Department of Anesthesiology, the Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China;

Department of Respiration, the Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China;

Department of Anesthesiology, the Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China;

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中图分类外科学;
关键词
magnesium sulfate; ischemia-reperfusion injury; apoptosis; caspase-3; bax; bcl-2;

机译：硫酸镁;缺血再灌注损伤;凋亡;caspase-3;bax;bcl-2;

Effects of magnesium sulfate on neuron apoptosis and expression of caspase-3,bax and bcl-2 after cerebral ischemia-reperfusion injury

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