Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss

Yong-qiang Yu; Huai-an Yang; Ming Xiao; Jing-wei Wang; Dong-yan Huang; Yagesh Bhambhani; Lyn Sonnenberg

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Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss

机译：感觉神经性听力损失的遗传效应和感觉神经性听力损失的循证治疗

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In this article, the mechanism of inheritance behind inherited hearing loss and genetic susceptibility in noise-induced hearing loss are reviewed. Conventional treatments for sensorineural hearing loss (SNHL), i.e. hearing aid and cochlear implant, are effective for some cases, but not without limitations. For example, they provide little benefit for patients of profound SNHL or neural hearing loss, especially when the hearing loss is in poor dynamic range and with low frequency resolution. We emphasize the most recent evidence-based treatment in this field, which includes gene therapy and allotransplantation of stem cells. Their promising results have shown that they might be options of treatment for profound SNHL and neural hearing loss. Although some treatments are still at the experimental stage, it is helpful to be aware of the novel therapies and endeavour to explore the feasibility of their clinical application.

机译：本文综述了遗传性听力损失背后的遗传机制和噪声诱发的听力损失的遗传易感性。感音神经性听力损失（SNHL）的常规治疗，即助听器和人工耳蜗，在某些情况下有效，但并非没有局限。例如，它们对于严重的SNHL或神经性听力损失的患者几乎没有益处，尤其是当听力损失在较差的动态范围内且具有低频分辨率时。我们强调该领域最新的循证治疗，包括基因治疗和干细胞同种异体移植。他们令人鼓舞的结果表明，它们可能是深层SNHL和神经性听力损失的治疗选择。尽管某些治疗仍处于实验阶段，但了解新疗法是有帮助的，并努力探索其临床应用的可行性。

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《中国医学科学杂志（英文版）》 |2015年第3期|179-188|共10页
作者
Yong-qiang Yu; Huai-an Yang; Ming Xiao; Jing-wei Wang; Dong-yan Huang; Yagesh Bhambhani; Lyn Sonnenberg;
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作者单位

Department of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine,University of Alberta, Edmonton, AB T6G 2B7, Canada;

Department of Otolaryngology, The First Affiliated Hospital,China Medical University, Shenyang 110001, China;

Department of Surgery, The People's Hospital of Liaoning Province,Shenyang 110016, China;

Department of Obstetrics and Gynecology,University of Alberta, Edmonton, AB T6G 2B7, Canada;

Department of Otolaryngology-Head & Neck Surgery,PLA General Hospital, Beijing 100853, China;

Department of Communication Sciences and Disorders, Faculty of Rehabilitation Medicine,University of Alberta, Edmonton, AB T6G 2B7, Canada;

Department of Developmental Pediatrics,Glenrose Rehabilitation Hospital, Edmonton, AB T5G 0B7, Canada;

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收录信息中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
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正文语种 eng
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Genetic Effects on Sensorineural Hearing Loss and Evidence-based Treatment for Sensorineural Hearing Loss

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