Factors Associated with Coronary Artery Disease in Young Population (Age≤40):Analysis with 217 Cases

Wei-xian Yang; Zheng Yang; Yong-jian Wu; Shu-bin Qiao; Yue-jin Yang; Ji-lin Chen

摘要

Objective To investigate the relevant factors of coronary artery disease (CAD) in young people under 40 years of age. Methods The study population was 292 young patients accepting coronary angiography in Fuwai Hospital from July to December 2006, including 272 men and 20 women, with the mean age being 36.7±3.7 years. The diagnosis of CAD was made in the cases presenting ≥50%stenosis in coronary lumen in coronary angiography. Based on the diagnosis, 217 patients (204 men, 13 women) were assigned to CAD group, and 75 (68 men, 7 women) to non-CAD group. Clinical data and metabolic characteristics of the patients were collected and analyzed using t-test,χ2 test, and multinomial logistic regression with SPSS 8.0 software. Results Most study subjects were current smokers (209/292, 71.6%), and more than half had body mass index (BMI)>24 kg/m2 (230/292, 78.8%) and usually took high-fat diet (162/292, 55.5%). The proportion of heavy smokers (smoking history ≥10 years and ≥20 cigarettes per day) were significantly higher in the CAD group than in the non-CAD group [20.7%(45/217) vs. 9.3%(7/75), P=0.015)]. Heavy smoking [odds ratio (OR), 1.89;95%confidence interval (CI), 1.74-2.05], hypertension (OR, 1.56;95%CI, 1.48-1.65), alcohol (OR, 1.37;95%CI, 1.30-1.46), type 2 diabetes mellitus (OR, 1.37;95%CI, 1.25-1.50), high-fat diet (OR, 1.35;95% CI, 1.28-1.43), and BMI>24 kg/m2 (OR, 1.09;95% CI, 1.03-1.17) were factors related to CAD in the young patients (all P<0.05). Total cholesterol (4.56±1.46 mmol/L vs. 4.09±1.00 mmol/L), low-density lipoprotein cholesterol (2.38±1.11 mmol/L vs. 2.14±0.63 mmol/L), lipoprotein a (134.97±109.70 mg/L vs. 101.58±58.39 mg/L), uric acid (359.89±100.09 μmol/L vs. 336.75±94.36μmol/L), erythrocyte sedimentation rate (9.98±12.19 mm/hour vs. 4.89±4.92 mm/hour), high-sensitivity C-reactive protein (3.42±4.39 mg/L vs. 2.80±3.77 mg/L) and Big endothelin-1 (1.41±1.50 fmol/mL vs. 0.77±1.13 fmol/mL) in plasma were significantly increased in the CAD group compared with the non-CAD group (all P<0.05). Conclusions Heavy smoking, hypertension, alcohol consumption, type 2 diabetes mellitus, high-fat diet and BMI>24 kg/m2 were significantly related to CAD in patients aged ≤ 40, with heavy smoking presenting the highest OR. Metabolic syndrome and inflammation were also more common in young CAD patients than in non-CAD patients.

机译：目的探讨40岁以下年轻人冠心病（CAD）的相关因素。方法研究对象为2006年7月至2006年12月在阜外医院接受冠脉造影的292例青年患者，其中男性272例，女性20例，平均年龄36.7±3.7岁。在冠状动脉造影中发现冠状动脉腔内狭窄≥50％的病例可诊断为CAD。根据诊断，将217例患者（204例男性，13例女性）分为CAD组，将75例（68例男性7例女性）分为非CAD组。收集患者的临床数据和代谢特征，并使用t检验，χ2检验和SPSS 8.0软件进行多项逻辑回归分析。结果大多数研究对象是现时吸烟者（209 / 292，71.6％），一半以上的体重指数（BMI）> 24 kg / m2（230 / 292，78.8％），通常采用高脂饮食（162 / 292，55.5％）。 CAD组的重度吸烟者比例（每天有≥10年的吸烟历史和每天≥20支香烟）比非CAD组显着更高[20.7％（45/217）比9.3％（7/75）， P = 0.015）]。重度吸烟[比值比（OR），1.89; 95％置信区间（CI），1.74-2.05]，高血压（OR，1.56; 95％CI，1.48-1.65），酒精（OR，1.37; 95％CI，1.30） -1.46），2型糖尿病（OR，1.37; 95％CI，1.25-1.50），高脂饮食（OR，1.35; 95％CI，1.28-1.43）和BMI> 24 kg / m2（OR， 1.09; 95％CI，1.03-1.17）是年轻患者中与CAD相关的因素（所有P <0.05）。总胆固醇（4.56±1.46 mmol / L对4.09±1.00 mmol / L），低密度脂蛋白胆固醇（2.38±1.11 mmol / L对2.14±0.63 mmol / L），脂蛋白a（134.97±109.70 mg / L） vs. 101.58±58.39 mg / L），尿酸（359.89±100.09μmol/ L vs. 336.75±94.36μmol/ L），红细胞沉降率（9.98±12.19 mm / hour vs.4.89±4.92 mm / hour），高血浆中C敏感蛋白（3.42±4.39 mg / L vs. 2.80±3.77 mg / L）和大内皮素-1（1.41±1.50 fmol / mL vs. 0.77±1.13 fmol / mL）在血浆中显着增加CAD组与非CAD组比较（均P <0.05）。结论结论≤40岁的患者中，重度吸烟，高血压，饮酒，2型糖尿病，高脂饮食和BMI> 24 kg / m2与CAD显着相关，其中重度吸烟的OR最高。在年轻的CAD患者中，代谢综合征和炎症也比非CAD患者更普遍。

Factors Associated with Coronary Artery Disease in Young Population (Age≤40):Analysis with 217 Cases

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