Probiotics’ Preventive Effect on Pediatric Food Allergy:A Meta-analysis of Randomized Controlled Trials

Xiang-yi Kong; Yi Yang; Jian Guan; Ren-zhi Wang

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Probiotics’ Preventive Effect on Pediatric Food Allergy:A Meta-analysis of Randomized Controlled Trials

机译：益生菌对小儿食品过敏的预防作用：一项随机对照试验的荟萃分析

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Objective To investigate the preventive effect of probiotics on pediatric food allergy. Methods From MEDLINE bibliographical database, we searched and reviewed all randomized controlled trials on the preventive effects of probiotics on pediatric food allergies up to September 2013 and excluded the studies that do not meet inclusion criteria and extracted the data. Meta-analysis for the results of homogenous studies was performed using RevMan 5.0 and the co-effect was pooled by using fixed-effects model of relative risk (RR) ratios. Results Ten trials published between 2007 and 2012 including 2701 cases were included. Meta-analysis based on included data showed that the preventive effect of prenatal and postnatal probiotic supplementation on food allergies was not significant with the RR=0.88 (95%CI:0.76-1.03). Conclusion Present evidences cannot show in unequivocal terms that prenatal and postnatal probiotic supplementation will prevent food allergic diseases.

机译：目的探讨益生菌对小儿食物过敏的预防作用。方法从MEDLINE书目数据库中，我们搜索并审查了截至2013年9月的所有关于益生菌对儿科食物过敏的预防作用的随机对照试验，并排除了不符合纳入标准的研究并提取了数据。对均质研究结果的荟萃分析使用RevMan 5.0进行，并且通过使用相对风险（RR）比率的固定效应模型来合并协同效应。结果纳入2007年至2012年之间发表的10项试验，包括2701例。基于纳入数据的荟萃分析表明，产前和产后补充益生菌对食物过敏的预防作用不显着，RR = 0.88（95％CI：0.76-1.03）。结论结论目前的证据不能明确地表明产前和产后补充益生菌可以预防食物过敏性疾病。

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《中国医学科学杂志（英文版）》 |2014年第3期|144-147|共4页
作者
Xiang-yi Kong; Yi Yang; Jian Guan; Ren-zhi Wang;
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Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

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收录信息中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
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Probiotics’ Preventive Effect on Pediatric Food Allergy:A Meta-analysis of Randomized Controlled Trials

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