• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>中国医学科学杂志（英文版） >Clinicopathological Analysis of 155 Patients with Persistent Isolated Hematuria
【24h】

Clinicopathological Analysis of 155 Patients with Persistent Isolated Hematuria

机译：155例持续性孤立性血尿患者的临床病理分析

获取原文
获取原文并翻译 | 示例
       
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Objectives To reveal etiologies of persistent isolated hematuria (PIH) through ultrastructural pathological examination, to disclose clinicopathological correlation in cases with PIH, and to summarize appropriate management of patients with PIH. Methods we retrospectively studied 155 PIH patients receiving renal biopsy between January, 2003 and December, 2008 in Peking Union Medical College Hospital. All the clinical data and follow-up result were analyzed. Results All subjects included 38 children and 117 adults, with mean age of 11.38±3.25 years for children and 35.17±8.44 years for adults. Thin basement membrane nephropathy (TBMN) was the most common pathology (55.3% of children and 49.6% of adults), followed by IgA nephropathy (18.4% of children and 32.5% of adults, mainly grade 2-3) and mesangial proliferative glomerulonephritis (MsPGN) without IgA deposition (13.2%of children and 12.8%of adults). Besides, Alport syndrome (2.6%of children) and membrane nephropathy (2.6%of children and 0.9%of adults) were demonstrated as other causes of PIH. Elevated mean arteral pressure or protein excretion rate, as well as episodic macrohematuria, indicated higher risk for MsPGN rather than TBMN. On the other hand, severity of microhematuria was irrelevant to pathological types of PIH. Totally, 86 patients were followed up and 37 cases therein stayed on track for long term (mean duration 41.11±28.92 months, range 8-113 months). Most cases had benign clinical course except 3 cases with TBMN, 5 cases with IgA nephropathy, 1 case with MsPGN (without IgA deposition), and 1 case with Alport syndrome, who developed hypertension or proteinuria. All of them were administered timely intervention. Conclusions Close follow-up should be required as the primary management for PIH. Equally important is careful monitoring for early identification of undesirable predictors;while renal biopsy and other timely intervention are warranted if there is hypertension, significant proteinuria or renal impairment.
机译：目的通过超微结构病理检查揭示持续性孤立性血尿（PIH）的病因，揭示PIH患者的临床病理相关性，并总结对PIH患者的适当治疗。 方法我们回顾性研究了2003年1月至2008年12月在北京协和医院收治的155例PIH患者的肾活检。分析所有的临床资料和随访结果。 结果所有受试者包括38名儿童和117名成人，儿童的平均年龄为11.38±3.25岁，成人的平均年龄为35.17±8.44岁。薄基底膜肾病（TBMN）是最常见的病理（55.3％的儿童和49.6％的成年人），其次是IgA肾病（18.4％的儿童和32.5％的成年人，主要是2-3级）和肾小球膜增生性肾小球肾炎（没有IgA沉积的MsPGN）（13.2％的儿童和12.8％的成人）。此外，还证实了阿尔波特综合征（占儿童的2.6％）和膜性肾病（占儿童的2.6％，占成年人的0.9％）是引起PIH的其他原因。平均动脉压或蛋白质排泄率升高，以及偶发性大血尿，表明MsPGN而不是TBMN的风险更高。另一方面，微血尿的严重程度与PIH的病理类型无关。总共对86例患者进行了随访，其中37例患者长期处于正常状态（平均持续时间41.11±28.92个月，范围8-113个月）。除3例TBMN，5例IgA肾病，1例MsPGN（无IgA沉积）和1例患有高血压或蛋白尿的Alport综合征外，大多数病例具有良好的临床病程。他们都受到及时干预。 结论结论应该密切随访作为PIH的主要管理方法。同样重要的是要仔细监测以尽早发现不良预测因素;同时，如果存在高血压，大量蛋白尿或肾功能不全，则必须进行肾脏活检和其他及时干预。

著录项

  • 来源
    《中国医学科学杂志（英文版）》 |2014年第3期|148-155|共8页
  • 作者

    Rong-rong Li; Hang Li; Yu-bin Wen; Qing-yuan Huang; Lin Duan; Yan Li;

  • 作者单位

    Department of Clinical Nutrition, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

    Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

    Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

    Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

    Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

    Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences&Peking Union Medical College, Beijing 100730, China;

  • 收录信息 中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号