Progress of Targeting Transforming Growth Factor-β1 Small Interfering RNA in Liver Fibrosis

Xuan Zhou; Xue-feng Yang

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Progress of Targeting Transforming Growth Factor-β1 Small Interfering RNA in Liver Fibrosis

机译：肝纤维化靶向转化生长因子β1小干扰RNA的研究进展

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Liver fibrosis is a common pathological consequence of a variety of chronic stimuli, including viral, autoimmune, drug-induced, cholestatic and metabolic diseases. Fibrosis is driven by a dynamic process involving increased synthesis of matrix components and a failure of physiological mechanisms of matrix turnover. Activation of hepatic stellate cells (HSCs) remains a central event in fibrosis. HSCs are the main source of extracellular matrix (ECM). Transforming growth factor-beta (TGF-β), which is the fibrogenic master cytokine, can induce the activation of HSCs to produce a large amount of ECM, and is capable of inducing apoptosis of liver cells. RNA interference (RNAi) is a novel gene disruption technology. Studies have shown that small interfering RNA (siRNA) targeting TGF-β1 may inhibit the activation and proliferation of HSCs, suppress ECM synthesis and block liver fibrosis. TGF-β1 siRNA-mediated gene silencing therapy provides a new avenue for liver fibrosis. This review summarizes recent progresses in research on HSCs, TGF-β1 and TGF-β1 siRNA in liver fibrosis.

机译：肝纤维化是多种慢性刺激的常见病理结果，包括病毒性，自身免疫性，药物诱导性，胆汁淤积性和代谢性疾病。纤维化是由一个动态过程驱动的，该过程涉及基质成分合成的增加以及基质周转的生理机制的失败。肝星状细胞（HSC）的激活仍然是纤维化的中心事件。造血干细胞是细胞外基质（ECM）的主要来源。转化生长因子-β（TGF-β）是纤维化的主细胞因子，可诱导HSC活化，从而产生大量ECM，并能够诱导肝细胞凋亡。 RNA干扰（RNAi）是一种新颖的基因破坏技术。研究表明，靶向TGF-β1的小干扰RNA（siRNA）可能抑制HSC的激活和增殖，抑制ECM合成并阻止肝纤维化。 TGF-β1siRNA介导的基因沉默疗法为肝纤维化提供了新途径。综述了肝纤维化中HSC，TGF-β1和TGF-β1siRNA的最新研究进展。

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《中国医学科学杂志（英文版）》 |2014年第4期|231-235|共5页
作者
Xuan Zhou; Xue-feng Yang;
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Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421002, China;

Department of Gastroenterology, Affiliated Nanhua Hospital, University of South China, Hengyang, Hunan 421002, China;

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收录信息中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
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Progress of Targeting Transforming Growth Factor-β1 Small Interfering RNA in Liver Fibrosis

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