Neurotoxicity and Biomarkers of Lead Exposure:a Review

Kang-sheng Liu; Jia-hu Hao; Yu Zeng; Fan-chun Dai; Ping-qing Gu

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Neurotoxicity and Biomarkers of Lead Exposure:a Review

机译：铅暴露的神经毒性和生物标志物：综述

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Appropriate selection and measurement of lead biomarkers of exposure are critically important for health care management purposes, public health decision making, and primary prevention synthesis. Lead is one of the neurotoxicants that seems to be involved in the etiology of psychologies. Biomarkers are generally classified into three groups:biomarkers of exposure, effect, and susceptibility.The main body compartments that store lead are the blood, soft tissues, and bone;the half-life of lead in these tissues is measured in weeks for blood, months for soft tissues, and years for bone. Within the brain, lead-induced damage in the prefrontal cerebral cortex, hippocampus, and cerebellum can lead to a variety of neurological disorders, such as brain damage, mental retardation, behavioral problems, nerve damage, and possibly Alzheimer’s disease, Parkinson’s disease, and schizophrenia. This paper presents an overview of biomarkers of lead exposure and discusses the neurotoxic effects of lead with regard to children and adults.

机译：适当的选择和曝光铅生物标志物的测量对于卫生保健管理的目的，公共卫生决策，以及一级预防合成至关重要。铅是似乎与心理学的病因有关的神经毒性物质之一。生物标志物通常分为三类：暴露，作用和敏感性的生物标志物。储存铅的主体腔室是血液，软组织和骨骼;这些组织中铅的半衰期以周为单位测量血液，软组织需要数月，而骨骼需要数年。在大脑中，铅诱导的前额叶大脑皮层，海马和小脑的损伤可导致多种神经系统疾病，例如脑损伤，智力低下，行为问题，神经损伤，可能还包括阿尔茨海默氏病，帕金森氏病和精神分裂症。本文概述了铅暴露的生物标志物，并讨论了铅对儿童和成人的神经毒性作用。

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《中国医学科学杂志（英文版）》 |2013年第3期|178-188|共11页
作者
Kang-sheng Liu; Jia-hu Hao; Yu Zeng; Fan-chun Dai; Ping-qing Gu;
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作者单位

State Key Laboratory of Reproductive Medicine, Department of Clinical Laboratory, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China;

Department of Maternity and Child Health Care, School of Public Health, Anhui Medical University, Hefei 230032, China;

Child Health Care Department, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China;

Obstetrical Department, Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China;

Department of Epidemiological and Health Statistics, School of Public Health of Nanjing Medical University, Nanjing 210029, China;

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收录信息中国科学引文数据库(CSCD);中国科技论文与引文数据库(CSTPCD);
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正文语种 eng
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Neurotoxicity and Biomarkers of Lead Exposure:a Review

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