Both the 5th and 6th Editions of TNM Staging System Fail to  Independently Predict Long-term Prognosis after Radical Hepatectomy in Hepatocellular Carcinoma Sized 〉 or = 5 cm

Li Zhou; Jing-an Rui; Da-xiong Ye; Shao-bin

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Both the 5th and 6th Editions of TNM Staging System Fail to Independently Predict Long-term Prognosis after Radical Hepatectomy in Hepatocellular Carcinoma Sized 〉 or = 5 cm

机译：TNM分期系统的第5版和第6版均无法独立预测肝细胞癌根治性肝切除术后长期预后〉或= 5 cm

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Objective To validate the predictive power of the 5th and 6th editions of TNM staging system(TNM-5,TNM-6) in a Chinese patient cohort with hepatocellular carcinoma(HCC) sized > or = 5 cm after radical hepatectomy.Methods Consecutive 121 patients with HCC sized > or = 5 cm undergoing radical hepatectomy between January 1995 and December 2002 were included.The impact of clinicopathological variables on prognosis was determined by univariate and multivariate analyses,after excluding 2 perioperative deaths.Results In univariate analysis,TNM-5 stage did not show prognostic significance for overall or disease-free survival,as opposed to TNM-6 stage,Edmondson-Steiner grade,portal vein tumor thrombosis(PVTT),vascular invasion,satellite nodule,Child-Pugh grade,and hepatitis B surface antigen(HBsAg) positivity.When these significant variables were entered in multivariate analysis,Edmondson-Steiner grade was the sole independent prognosticator for both overall and disease-free survival,whereas Child-Pugh grade independently influenced disease-free survival.However,TNM-6 stage lost its predictive potential in multivariate analysis.Conclusions Neither TNM-5 nor TNM-6 staging system is revealed to be independently prognostic in patients with HCC sized > or = 5 cm after radical hepatectomy.Therefore,TNM-6 calls for more support in many subsets of HCC patients.

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《中国医学科学杂志：英文版》 |2009年第4期|P.220-226|共7页
作者
Li Zhou; Jing-an Rui; Da-xiong Ye; Shao-bin;
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作者单位

Department;

of;

General;

Surgery;

Department;

of;

Pathology,;

Peking;

Union;

Medical;

College;

Hospital,;

Chinese;

Academy;

of;

Medical;

Sciences;

＆;

Peking;

Union;

Medical;

College,;

Beijing;

100032,;

China;

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原文格式 PDF
正文语种 CHI
中图分类 S858.285.3;
关键词
原发性肝癌; TNM; 预后; 系统; Steiner; 切除术; 多因素分析; 尺寸;

机译：原发性肝癌;TNM;预后;系统;Steiner;切除术;多因素分析;尺寸;

Both the 5th and 6th Editions of TNM Staging System Fail to Independently Predict Long-term Prognosis after Radical Hepatectomy in Hepatocellular Carcinoma Sized 〉 or = 5 cm

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