首页> 中文期刊> 《中国医学科学杂志:英文版》 >Wnt5a Plays Controversial Roles in Cancer Progression

Wnt5a Plays Controversial Roles in Cancer Progression

         

摘要

WntSa is a representative Wnt ligand that regulates multiple cellular functions through the Wnt5a nonclassical pathway.Although Wnt5a has been implicated in various pathological conditions,its role in cancer is ambiguous and might involve methyl modifications,distinct mRNA isofbrms,as well as different downstream pathways.Therefore,it is an essential factor in cancers'progression(invasion,migration,proliferation,and epithelial-mesenchymal transition),and a potential biomarker for prognosis and treatment.

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