首页> 中文期刊> 《中国药理学通报》 >Ⅰ型单纯疱疹病毒潜伏感染及其应激复发

Ⅰ型单纯疱疹病毒潜伏感染及其应激复发

         

摘要

Herpes simplex virus type Ⅰ(HSV-1) is a common pathogen, and human is the only natural host of it.Following a period of lytic replication in epithelial cells, HSV-1 enters axon terminals of sensory neurons and then travels via retrograde transport to the sensory ganglia where latency can be established.Upon the stimulation of some stressors, the latent virus can reactivate, leading to recurrent diseases.Therefore, to clarify the mechanism of HSV-1 latent infection and stress-induced reactivation will offer new insights into the prevention, treatment and control of HSV-1 infection.In this review, we describes the mechanisms underlying HSV-1 latent infection and stress-induced reactivation.%Ⅰ型单纯疱疹病毒(HSV-1)是常见的病原体,人是其唯一自然宿主.原发感染后,HSV-1在上皮细胞大量复制,然后沿轴突逆行至感觉神经节并潜伏下来.当机体在一定的应激负荷下,潜伏感染的病毒重新激活,从而造成复发性疾病.因此,阐明病毒潜伏感染及应激复发的相关机制,将对Ⅰ型单纯疱疹病毒预防、治疗和控制带来新的启示.该文就HSV-1潜伏感染与应激复发的相关机制进行综述.

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