糖尿病心肌病(diabetic cardiomyopathy,DCM)是相对于冠状动脉粥样硬化心脏病、高血压心脏病、心脏瓣膜性病变、先天心脏病及其他一致心脏疾病与糖尿病特异相关的心肌性病变来说独立存在的疾病,病理表现为心肌代谢紊乱以及微血管病变所致的心肌细胞肥大、间质纤维化、坏死和凋亡.内质网是多种重要细胞功能的中心场所,糖尿病患者心肌细胞内的内质网肿胀、出现功能紊乱,高血糖状态能引发内质网应激(endoplasmic reticulum stress,ERS),提示ERS可能参与DCM进程的发生和发展.基于此,该文从糖尿病心肌病的发病机制、未折叠蛋白反应、DCM中ERS的相关作用等方面综述了ERS在糖尿病心肌病中的研究进展.%Diabetic cardiomyopathy(DCM) is a disease independently related with coronary artery atherosclerotic heart disease, hypertensive heart disease, valvular heart disease, congenital heart disease and other heart diseases that are uniquely associated with diabetes mellitus, and the pathological manifestations of DCM are mainly myocardial hypertrophy, interstitial fibrosis, necrosis and apoptosis.Endoplasmic reticulum is the central location of many important cellular functions, and endoplasmic reticulum swelling and functional disorder in diabetic cardiomyocytes, high blood sugar can cause endoplasmic reticulum stress, suggesting that endoplasmic reticulum stress(ERS) may be involved in the pathogenesis of diabetic cardiomyopathy and development.Based on this, this paper summarizes the progress of ERS in diabetic cardiomyopathy from the pathogenesis of diabetic cardiomyopathy, unfolding protein reaction and the related role of ERS in DCM.
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