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首页> 中文期刊> 《中国药理学通报》 >越鞠甘麦大枣汤对抑郁子代小鼠海马Akt及 m-TOR分子表达的影响

越鞠甘麦大枣汤对抑郁子代小鼠海马Akt及 m-TOR分子表达的影响

         
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Aim To observe the rapid antidepressant effect of Yuejuganmaidazao Decoction on postpatum de-pression offspring , and analyze its influence on the Akt and mTOR expression .Methods After postpartum de-pression model was established , the offsprings were randomly divided into the following groups: control group(CTL-F1,n =8), vehicle group (Veh,n =8) and YG group ( YG, n =8 ) .Veh group was treated with vehicle , YG group was treated with Yueju gan-maidazao Decoction(8.3 g· kg -1 ).Forced swimming test(FST) was measured 24 hours after single adminis-tration.The phosphorylation and total level of Akt and m-TOR in the hippocampus was detected by Western blot.Results The immobility time in YG group was significantly shorter than that in Veh group ( P <0.01 ) , and the expression of p-Akt and p-mTOR in the hippocampus was significantly increased ( P <0.05 ) .Conclusion Yuejuganmaidazao Decoction may rapidly alleviate depression-like behaviors of PPD offsprings through upregulation of Akt and mTOR ex-pression .%目的观察越鞠甘麦大枣汤对子代抑郁症的快速疗效，并分析其对Akt及mTOR分子的影响。方法成功建立产后抑郁子代模型后，随机分组如下：正常子代组（ CTL-F1，8只），抑郁子代生理盐水组（Veh，8只）、越鞠甘麦大枣汤组（ YG，8只）。 Veh组给予生理盐水， YG组给予越鞠甘麦大枣汤（8.3 g· kg－1）。单次给药24 h后测量强迫游泳实验（FST）。取脑，Western blot 法检测小鼠海马Akt 及m-TOR的磷酸化及总体水平。结果 YG组的游泳不动时间比Veh组明显缩短（ P＜0.01），并且小鼠海马p-Akt和p-mTOR表达明显上调（ P＜0.05）。结论越鞠甘麦大枣汤可能通过上调Akt和mTOR表达，快速缓解子代抑郁样行为。

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