目的 研究佛司可林、异佛司可林、佛司可林G、J、A、I对磷酸组胺(His)、氯化乙酰胆碱(ACh)引起的离体豚鼠气管条收缩作用的影响.方法 取豚鼠气管制成螺旋状气管条,用磷酸组胺、氯化乙酰胆碱诱发气管条收缩,按累积剂量法加入系列浓度的佛司可林、异佛司可林、佛司可林G、J、A、I,观察其对气管条收缩反应的舒张作用,记录各累积浓度下的量效曲线,计算解痉百分率.结果 异佛司可林、佛司可林均能明显舒张由His、ACh引起的离体豚鼠气管条的收缩(P<0.01).佛司可林G、J、A、I均能舒张由His引起的离体豚鼠气管条的收缩(P<0.01).且随着剂量的增加,舒张作用也有所增强.结论 佛司可林、异佛司可林、佛司可林G、J、A、I对His或ACh引起的离体豚鼠气管条的收缩均具有舒张作用.%Aim To investigate the relaxation effects of forskolin, isoforskolin, forskolin G, J, A, I on isolated bronchioles in guinea pig. Methods The contraction of spiral tracheal strips of guinea pig was induced by histamine diphosphate ( His )and acetylcholimium chloride ( ACh ). The laxation effects of forskolin, isoforskolin, forskolin G, J, A, I on tracheal smooth muscle were observed respectively by recording dose-response curve of each cumulative concentration and calculating the antispasmodic percentage. Results Forskolin and isoforskolin could significantly inhibit the contraction ofrnisolated guinea pig trachea induced by His and ACh ( P <0. 01 ). Forskolin G, J, A, I also could significantly inhibit the contraction of isolated guinea pig trachea induced by His ( P < 0. 01 ). The data showed a correlation between concentration and antispasmodic percentage. Conclusion Forskolin, isoforskolin, forskolin G, J, A, I can relax the contraction of isolated guinea pig trachea induced by His or ACh.
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