Dendritic cells ( DCs ) are the most powerful professional antigen presenting cell ( APC ), which have immunogenic and tolerogenic function in immune system. As a professional APC, the immunogenic DC presents self-antigen abnormally and results in immune system disorder. The immunogenic function may be one pathogenesis of RA. On the other hand, the tolerogenicity of DC could induce antigen specific T cell deletion, an-rnergy and produce regulatory T cells ( Tregs ), which make DCs play a regulatory role in RA. This paper makes an introduction about how DCs are involved and play a regulatory role in the pathogenesis of RA.%树突细胞(dendritic cells,DCs)是体内功能最强大的专职抗原提呈细胞( antigen-presenting cell,APC),具有免疫原性和耐受性双重作用.DCs的免疫原性体现在作为专职APC对自身抗原异常提呈,引起机体免疫系统紊乱,是参与类风湿关节炎( rheumatoid arthritis,RA)发生的一个重要原因;DCs的耐受性则体现在通过多种机制诱导抗原特异性T细胞消除、无能及调节性T细胞(regulatory T cells,Tregs)的产生,导致免疫耐受,发挥对RA的调控作用.该文结合该课题组的研究结果对DCs参与RA的发病机制以及在RA病理机制中的调控作用方面进行介绍和评论.
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