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《中国药学：英文版》
>The Binding Ability and Inclusion complexation Behavior of Curcumin with Natural α—，β—，γ—Cyclodextrins and Organoselenium—Bridged Bis（β—cyclodextrin）s
The Binding Ability and Inclusion complexation Behavior of Curcumin with Natural α—，β—，γ—Cyclodextrins and Organoselenium—Bridged Bis（β—cyclodextrin）s
Aim：To investigate quantitatively the binding ability and inclusion complexation behavior of curcumin with natural α-，β-，γ-cyclodextrins(1-3) and a series of organoselenium-bridged bit(β-cyclodextrin)s with simple spacer (4-6).Methods:The spectrophotometric titrations have been performed in KCl-HCl buffer solutioln(pH=2.0) at 25℃ to calculate the complex stability constants(Ks) and Gibbs free energy changes(ΔG°) for the stoichiometric 1:1 incluon complexation of 1-6 with curcumin.Results:The binding ability of β-cyclodextrin for inclusion complexation with guest curcumin is higher than that of α-and γ-cyclodextrinms.As compared with parent β-cyclodextrin for inclusion complexation with guest curcumin is higher than that of α-and γ-cyclodextrins.As compared with parent β-cyclodextrin by a factor 2.8-17.1,Conclusion:Size/shape fit and hydrophobic interaction between host cyclodextrins and guest curcumin molecule are the important factors affecting the binding ability and inclusion complex ation behavior of these cyclodextrins 1-6.
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